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The main objective of the proposed research is to extend our understanding of how gesture and language interact, focusing on the role of cognitive embodiment in this interaction, and to explore the neural systems that support links between language and actions systems.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS + semantic, motor, attentional tasks | Experimental | Combination of gestural (subjects have to indicate if the gesture is related to the word), attentional and motor tasks with anodal stimulation |
|
| Sham tDCS + semantic, motor, attentional tasks | Sham Comparator | Combination of gestural (subjects have to indicate if the gesture is related to the word), attentional and motor tasks with sham stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | Transcranial direct current stimulation (tDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| response time in semantic decision task | Comparing response time in semantic decision task under anodal tDCS compared to sham stimulation (change from sham stimulation) | assessed during stimulation or sham stimulation of semantic decision task (last approximately 10 min) at specific timepoint within 2 weeks |
| performance in attentional load task | Attentional load task: Participants are presented with a 6 positions ring that includes different shapes, they have to press V when they see a square and N when they see a diamond. They will have to ignore any shapes other than square and diamond within the ring or distractors that appear outside the ring. Comparing performance in attentional load task under anodal tDCS compared to sham stimulation (change from sham stimulation) | assessed during stimulation or sham stimulation of attentional load task (last approximately 6 min) at specific timepoint within 2 weeks |
| performance in motor task | Motor Task: Participants are presented with a red Box and they have to click a button each time they see it as fast as they can. Comparing performance in motor task under anodal tDCS compared to sham stimulation (change from sham stimulation) | assessed during stimulation or sham stimulation of motor task (last approximately 4 min) at specific timepoint within 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional connectivity predictors | Connectivity as measured by resting-state fMRI during baseline as predictors for performance and tDCS responsiveness | assessed during baseline testing |
| Other cognitive outcomes: change in working memory performance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Floeel, Prof | Charite Universitätsmedizin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité | Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25558040 | Background | Cohen-Maximov T, Avirame K, Floel A, Lavidor M. Modulation of Gestural-verbal Semantic Integration by tDCS. Brain Stimul. 2015 May-Jun;8(3):493-8. doi: 10.1016/j.brs.2014.12.001. Epub 2014 Dec 11. | |
| 12911767 | Background | Floel A, Ellger T, Breitenstein C, Knecht S. Language perception activates the hand motor cortex: implications for motor theories of speech perception. Eur J Neurosci. 2003 Aug;18(3):704-8. doi: 10.1046/j.1460-9568.2003.02774.x. |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| sham-tDCS | Device | sham stimulation |
|
|
Digit span backward performance assessed before (baseline) and after stimulation to test for tDCS effects on working memory
| change in working memory performance from baseline after 30 min (approximately) |
| Other cognitive outcomes: change in Attention performance | Digit span forward performance assessed before baseline) and after stimulation to test for tDCS effects on attention | change in attention performance from baseline after 30 min (approximately) |
| 18303984 | Background | Floel A, Rosser N, Michka O, Knecht S, Breitenstein C. Noninvasive brain stimulation improves language learning. J Cogn Neurosci. 2008 Aug;20(8):1415-22. doi: 10.1162/jocn.2008.20098. |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |