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| Name | Class |
|---|---|
| University of California, Davis | OTHER |
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The purpose of the study is to compare the changes in the appearance of dry skin after the use various moisturizers: white petrolatum ointment, coconut oil, jojoba oil, and almond oil in patients with dry skin.
The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| virgin coconut oil | Active Comparator | All subjects will apply virgin coconut oil to a previously randomize section of the skin on the left or right forearm. |
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| virgin jojoba oil | Active Comparator | All subjects will apply virgin jojoba oil to a previously randomize section of the skin on the left or right forearm |
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| virgin almond oil | Active Comparator | All subjects will apply virgin almond oil to a previously randomize section of the skin on the left or right forearm |
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| white petrolatum ointment | Active Comparator | All subjects will apply white petrolatum ointment to a previously randomize section of the skin on the left or right forearm. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| virgin coconut oil | Other | One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin coconut oil application twice daily for 2 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| The appearance of xerosis | The clinical severity of xerosis of the 4 location will be graded by a trained observed using a previously validated Dry Skin Scale and by analysis of the digital photos. | 14 days |
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| Measure | Description | Time Frame |
|---|---|---|
| Skin barrier biophysical properties of xerosis | Transepidermal water loss (TEWL) and stratum corneum hydration status will be measured using hand-held, noninvasive, skin barrier measuring devices (Tewameter and moistureMeter) | 14 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vivian Y Shi, MD | University of Arizona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona, Banner-University Medical Center | Tucson | Arizona | 85704 | United States | ||
| University of California, Davis |
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| ID | Term |
|---|---|
| D004485 | Eczema |
| ID | Term |
|---|---|
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
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| virgin jojoba oil | Other | One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin jojoba oil application twice daily for 2 weeks. |
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| virgin almond oil | Other | One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive virgin almond oil application twice daily for 2 weeks. |
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| white petrolatum ointment | Other | One of the four locations (right proximal forearm, right distal forearm, left proximal forearm, left distal forearm) on the forearm will be selected to receive white petrolatum ointment application twice daily for 2 weeks. |
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| Sacramento |
| California |
| 95816 |
| United States |