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With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered. Idiopathic normal pressure hydrocephalus (iNPH) is considered as one of reversible dementia, which can be hint by the surgery. In addition, dementia of iNPH is the typical subcortical dementia. Therefore exploring the pathogenic mechanism is conducive to the early diagnosis and treatment. This research is to monitor the changing of iNPHGS, cognitive function, walking ability as well as brain construction imaging and neural network before and after ventriculo-peritoneal shunting in order to demonstrate the pathogenesis of triads. In the process, the supplementary test, for instance, CSF tap test, will be validated the predictive value.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal pressure hydrocephalus | Included will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both The NPH patients will undergo the CSF tap test and then receive the ventriculo-peritoneal shunting surgery. They will have the examination of brain constructure neuroimaging and functional MRI prior to and posterior to the shunting. |
| |
| normal control | Healthy volunteers will undergo the examination of brain constructure and functional MRI. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ventriculo-peritoneal shunting | Procedure | A mainstream therapy for NPH. It involves the device of CSF flow control of shunts and accessories(CFDA(I)20143665605) |
|
| Measure | Description | Time Frame |
|---|---|---|
| The brain constructure and neural network changing one day after shunting |
| Day 1 after shunting |
| The brain constructure and neural network changing 90 days after shunting | Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI | Day 90 after shunting |
| The brain constructure and neural network changing one year after shunting | Using the voxel based morphology technique to measure the ventricular volume and brain lobe volume •Neural network( DMN)by the resting functional MRI | one year after shunting |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of the clinical syndrome of normal pressure hydrocephalus | iNPHGS | Day 1 after shunting |
| Assessment of the clinical syndrome of normal pressure hydrocephalus | iNPHGS |
| Measure | Description | Time Frame |
|---|---|---|
| Cognition assessments | The neuropsychological battery assessment (including MMSE, MOCA as well as cognitive domains especially executive function examinations) | Day 1 after shunting |
| Cognition assessments |
Inclusion Criteria:
ncluded will be subjects with a probable diagnosis of NPH. The diagnosis will be based primarily on presence of gait impairment plus at least one other impairment in urinary symptoms, cognition impairment or both.
Are 50 years old or older
Patients who understand the study protocol
Patients who meet the criteria for NPH
Exclusion Criteria:
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Patients with physical and cognitive symptoms and brain image findings (Brain CT or MRI) suggestive of NPH were evaluated at neurological outpatient clinic of Peking Union Medical College Hospital according to the NPH diagnosis criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caiyan Liu, MD | Contact | 8613161202662 | liucy-pumch@163.com | |
| Liling Dong, MD | Contact | 8613521801162 | sophi_d@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Jing Gao, MD | Department of Neurology, Peking Union Medical College Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | 100730 | China |
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| Day 90 after shunting |
| Assessment of the clinical syndrome of normal pressure hydrocephalus | iNPHGS | one year after shunting |
The neuropsychological battery assessment (including MMSE, MOCA as well as cognitive domains especially executive function examinations)
| Day 90 after shunting |
| Cognition assessments | The neuropsychological battery assessment (including MMSE, MOCA as well as cognitive domains especially executive function examinations) | one year after shunting |
| Walking ability evaluation | Including 10m walking test, up and go tests | Day 1 after shunting |
| Walking ability evaluation | Including 10m walking test, up and go tests | Day 90 after shunting |
| Walking ability evaluation | Including 10m walking test, up and go tests | one year after shunting |
| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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