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This study will assess the putative advantages of cerebellar stimulation on motor learning abilities of stroke patients. In order to have a control group to refer to, the effect of cerebellar stimulation on healthy young and old participants will also be assessed.
Cerebrovascular accidents (CVA) are the first cause of acquired disability in France. Despite rehabilitation interventions, a great proportion of patients suffers from motor disability in the upper limb. Recently, several studies have shown that post CVA patients exhibit great neural plasticity as a direct consequence of their condition.
Interestingly, the transcranial direct current stimulation (tDCS) is a non-invasive electro stimulation technique that allows for a modulation of cerebral activity. It has been shown that when applied to the cerebellum, tDCS increases learning performances of healthy subjects. Yet, motor rehabilitation after a CVA highly relies on motor (re)learning. The cerebellar tDCS thus appear as a promising method to enhance the performance of post-CVA motor learning and consequently the benefits of post-CVA rehabilitation.
The current study aims to promote the post CVA neural plasticity by using the tDCS in order to enhance motor learning of the upper limb.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS Post-CVA | Experimental | The participants will get a 20min stimulation at a maximal intensity of 2mA |
|
| Sham Post-CVA | Sham Comparator | The tDCS will be placed as for the Experimental group and will last 30 seconds at the beginning of task |
|
| tDCS Young Healthy | Experimental | The participants will get a 20min stimulation at a maximal intensity of 2mA |
|
| Sham Young Healthy | Sham Comparator | The tDCS will be placed as for the Experimental group and will last 30 seconds at the beginning of task |
|
| tDCS Older Healthy | Experimental | The participants will get a 20min stimulation at a maximal intensity of 2mA |
|
| Sham Older Healthy | Sham Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| With stimulation | Device | ramp stimulation from 0 to 2 mA followed by 20 minutes of stimulation at 2mA while practicing during 3 of the 4 sessions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Force control | Measurement in Newton of the force applied by each finger. | Day 1 |
| Force control | Measurement in Newton of the force applied by each finger. | Day 2 |
| Force control | Measurement in Newton of the force applied by each finger. | Day 3 |
| Force control | Measurement in Newton of the force applied by each finger. | Day 10 |
| Overflow | Measurement in ms of the involuntary finger movements. | Day 1 |
| Overflow | Measurement in ms of the involuntary finger movements. | Day 2 |
| Overflow | Measurement in ms of the involuntary finger movements. | Day 3 |
| Overflow | Measurement in ms of the involuntary finger movements. | Day 10 |
| Measure | Description | Time Frame |
|---|---|---|
| Moberg Pick-up Test | Assessment of the functionality of the hand. One score will be given at the end of the test. | Day 1 |
| Moberg Pick-up Test | Assessment of the functionality of the hand. One score will be given at the end of the test. |
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Inclusion Criteria:
For "Post-AVC patients" :
Exclusion Criteria:
For "Post-AVC patients" :
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marion Verneau, PhD | Contact | +33140788663 | mverneau@gmail.com | |
| Marie GODARD | Contact | 00 33 1 45 65 77 28 | marie.godard@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Florence COLLE, MD | CHSA | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Recherche Clinique (CRC) - CHSA | Recruiting | Paris | 75014 | France |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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The tDCS will be placed as for the Experimental group and will last 30 seconds at the beginning of task |
|
| No stimulation | Device | ramp stimulation from 0 to 2 mA followed by 30 sec of stimulation at 2mA. |
|
| Day 2 |
| Moberg Pick-up Test | Assessment of the functionality of the hand. One score will be given at the end of the test. | Day 3 |
| Moberg Pick-up Test | Assessment of the functionality of the hand. One score will be given at the end of the test. | Day 10 |
| Action Research Arm Test | Assessment of the upper limb mobility. One score will be given at the end of the test | Day 1 |
| Action Research Arm Test | Assessment of the upper limb mobility. One score will be given at the end of the test | Day 2 |
| Action Research Arm Test | Assessment of the upper limb mobility. One score will be given at the end of the test | Day 3 |
| Action Research Arm Test | Assessment of the upper limb mobility. One score will be given at the end of the test | Day 10 |
| Finger time release | Time needed to release the finger force when needed (in ms). | Day 1 |
| Finger time release | Time needed to release the finger force when needed (in ms). | Day 2 |
| Finger time release | Time needed to release the finger force when needed (in ms). | Day 3 |
| Finger time release | Time needed to release the finger force when needed (in ms). | Day 10 |
| Service de Médecine Physique et Rédaptation | Not yet recruiting | Paris | 75014 | France |
|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |