SonR Based Stimulation-VECtor OPTimisation in CRT Patients

Effect of SonR Based Stimulation-VECtor OPTimisation in Patients With Chronically Implanted Cardiac Resynchronization Devices

The primary aim of the present study is to investigate whether the optimisation of LVSV in addition to the optimisation of AV-D and VV-D when using the device-based sensor technology mentioned above results in an improved clinical outcome of CRT. Moreover, noninvasive measurements are intended to evaluate hemodynamic differences between the different stimulation configurations using the Finapres® method.

Inclusion Criteria:

• Indication for CRT-D implantation according to guidelines at the time of implantation
• Implanted CRT-D system with SonR sensor technology
• Sinus rhythm
• NYHA class II-IV
• Age ≥ 18 years
• Written informed consent to participate in the study

Exclusion Criteria:

• Patients having received a CRT system without SonR sensor technology
• Patients with an insufficient SonR signal
• Confirmed pregnancy
• Age < 18 years
• Life expectancy < 1 year
• Atrial fibrillation / atrial flutter at the time of enrollment
• Unability to give informed consent
• Participation in another clinical study with active therapeutic arm
• Regular follow-up at the study site from enrolment to 12 months follow up not guaranteed