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Physical training may improve physical capacity and health parameters in various systemic autoimmune diseases. Therefore, the present study will assess the role of an exercise training program in patients with relapsing polychondritis.
Impact of physical training in patients with relapsing polychondritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Active Comparator | Patients will be submitted to physical training (12-weeks, twice/week) |
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| Control group | Active Comparator | Healthy individuals will be submitted to physical training (12-weeks, twice/week) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical training | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiopulmonary test | Patients will undertake a maximal graded exercise test on a treadmill, with increments in velocity and grade at every minute until volitional exhaustion. VO2peak will be considered as the average of the final 30 s of the test. Ventilatory threshold (VAT) will be determined when ventilatory equivalent for VO2 (VE/VO2) increased without a concomitant increase in ventilatory equivalent for carbon dioxide (VE/VCO2). Respiratory compensation point (RCP) will be determined when VE/VO2 and VE/VCO2 increased simultaneously. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Strength muscle tests | The dynamic 1-RM for the leg-press and the bench-press exercises, arm curl (with the dominant arm), and isometric strength (assessed by handgrip, with the dominant arm) will be assessed at baseline and after the intervention. | 12 weeks |
| Healthy Assessment Questionnaire (HAQ) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Samuel K Shinjo, PhD | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samuel Katsuyuki Shinjo | São Paulo | 01246903 | Brazil |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Patients will submitted to physical training (12-weeks, twice/week)
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Especific questionnaire to assess the quality of life. Pontuaction: 0.00-3.00 |
| 12 weeks |
| Functional muscle tests | Muscle function will be evaluated through the TUG and the TST tests | 12 weeks |
| Muscle biopsy | After local anesthesia, a cutaneous incision will be made in lateral thigh face. The biopsy will be done using the Bergstrom needle. Histological (hematoxylin and eosin)/immunohistochemical (CD4, CD8, CD68, CD20, C5b-9, MHCI, MHCII, CD31) analysis will be performed in muscle samples (at baseline and after 12 weeks) in all patients (present study) | 12 weeks |