Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. Evaluated the safety and preliminary efficacy of administering SVF and PRP intra-articularly into patients with osteoarthritis grade 1 and 2.

Inclusion Criteria:

• patients age 50 or older who present with symptomatic primary osteoarthritis of the knee
• daily pain for the previous 3 months
• analgesics usage at least once a week
• less than 30 minutes of morning stiffness
• WOMAC score of ≤ 75 in the target knee
• Brandt Radiographic Grading Scale of Osteoarthritis grade 1 and 2

Exclusion Criteria:

• evidence of secondary knee osteoarthritis
• severe osteoarthritis (Joint space width - JSW < 2 mm)
• prior intra articular injections within the previous one year prior to inclusion
• patients with clinically significant systemic disease