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This study has been administratively closed by the IRB as of 5/20/2019. This administrative closure was required because of the study expiration on 4/29/2019 and a continuing review application for re-approval of the study was not submitted.
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The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
Study Objectives:
We aim to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Participants with no history of Traumatic Brain Injury, Traumatic Spinal Cord Injury or Intracranial Neoplasm. A single draw of 5 mL of blood will be obtained as well as demographic information and a brief medical history to act as comparison data to the other groups. | ||
| Traumatic Brain Injury (TBI) | Patients with Acute Severe TBI (post-resuscitation GCS of 8 or less). Participants will have blood draws at the time points identified below:
In all cases, 5 mL of blood will be obtained from the participant. Demographic data will be collected, including:
| ||
| Spinal Cord Injury (SCI) | Patients with acute spinal cord injury (SCI) (post-resuscitation ASIA score of C, B or A). Participants will have blood draws at the time points identified below:
In all cases, 5 mL of blood will be obtained. Demographic data will be collected, including:
|
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| Measure | Description | Time Frame |
|---|---|---|
| Quantitate Autoantibodies | Quantitate CNS autoantibody development and temporal course in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Autoantibody Correlation | Characterize how CNS autoantibody levels correlate with specific injury patterns as well as radiographic and clinical measures of injury severity. | 5 years |
| Autoantibody Production and History |
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Inclusion Criteria:
Exclusion Criteria:
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Study population includes patients admitted to the University of Utah and its covered entities.
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| Name | Affiliation | Role |
|---|---|---|
| Gregory WJ Hawryluk, MD, Ph.D. | University of Utah | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Utah Hospital | Salt Lake City | Utah | 84132 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24507518 | Background | Robinson AP, Harp CT, Noronha A, Miller SD. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol. 2014;122:173-89. doi: 10.1016/B978-0-444-52001-2.00008-X. | |
| 15931160 | Background | Becker KJ, Kindrick DL, Lester MP, Shea C, Ye ZC. Sensitization to brain antigens after stroke is augmented by lipopolysaccharide. J Cereb Blood Flow Metab. 2005 Dec;25(12):1634-44. doi: 10.1038/sj.jcbfm.9600160. |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D013119 | Spinal Cord Injuries |
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Plasma
| Intracranial Neoplasm | Patients undergoing resection of intra-axial brain tumors (commonly gliomas such as glioblastoma multiforme, astrocytomas and oligodendrogliomas). All participants will have blood draws at the time points identified below:
In all cases, 5 mL of blood will be obtained. Demographic data will be collected, including:
|
Determine how intercurrent infection and a history of prior CNS insult affects the temporal course and magnitude of autoantibody production.
| 5 years |
| 21799171 | Background | Becker KJ, Kalil AJ, Tanzi P, Zierath DK, Savos AV, Gee JM, Hadwin J, Carter KT, Shibata D, Cain KC. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke. 2011 Oct;42(10):2763-9. doi: 10.1161/STROKEAHA.111.619593. Epub 2011 Jul 28. |
| 22849382 | Background | Giunta B, Obregon D, Velisetty R, Sanberg PR, Borlongan CV, Tan J. The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention. J Neuroinflammation. 2012 Aug 1;9:185. doi: 10.1186/1742-2094-9-185. |
| 2706482 | Background | Noble LJ, Wrathall JR. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res. 1989 Mar 13;482(1):57-66. doi: 10.1016/0006-8993(89)90542-8. |
| 12165135 | Background | Hayes KC, Hull TC, Delaney GA, Potter PJ, Sequeira KA, Campbell K, Popovich PG. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury. J Neurotrauma. 2002 Jun;19(6):753-61. doi: 10.1089/08977150260139129. |
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D013118 | Spinal Cord Diseases |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |