Not provided
Not provided
Not provided
Not provided
Not provided
Participating site withdrew prior to any enrollment and lead site with slow enrollment. Not expected to meet enrollment goals.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to collect information about how often an abnormal heart beat happens in children who have been burned.
The investigators hope to learn the following:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ≥30% TBSA burn injury | Experimental | For patients in Group 1 with ≥30% TBSA, a baseline Echocardiogram (ECHO) will be obtained approximately one week from admission and monthly (+/- 1 week) or at an interval determined by cardiology during the acute inpatient stay. ECHO tests will be discontinued after 3 negative exams or when discontinued by cardiology, whichever comes first. |
|
| <30% TBSA burn injury | No Intervention | For patients in Group 2 with <30% TBSA and presence of a cardiac abnormality standard clinical care appropriate for the type of arrhythmia will be followed. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiogram | Diagnostic Test | A baseline Echocardiogram test (ECHO) will be done one week from admission and monthly (+/- 1 week) or as ordered by a cardiologist. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of cardiac dysfunction in pediatric burn patients | Results of echocardiograms will be compared between patients with cardiac dysfunction versus those without cardiac dysfunction. | Through study completion up to 4 years after hospital discharge. |
| Measure | Description | Time Frame |
|---|---|---|
| Acute care hospital length of stay | Hospital length of stay (admission date to discharge date) will be compared between participants with cardiac dysfunction versus participants without cardiac dysfunction. | Hospital admission to discharge (average of 1 day per %TBSA burn - example 30 days for a 30% TBSA burn injury). |
Not provided
Inclusion Criteria:
Pediatric burn patients from age 0 - 18 who have sustained a burn injury will be eligible for this study.
Group 1 will consist of patients with ≥30% TBSA burn injury. Group 2 will consist of patients with <30% TBSA burn injury who develop a cardiac abnormality.
Exclusion Criteria:
Patients with pre-existing cardiac disorder, desquamative skin disorders and electrical injury.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Ivan Wilmot, MD | Shriners Hospitals for Children | Principal Investigator |
| Petra M Warner, MD | Shriners Hospitals for Children | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shriners Hospitals for Children | Cincinnati | Ohio | 45229 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16819352 | Background | Mak GZ, Hardy AR, Meyer RA, Kagan RJ. Reversible cardiomyopathy after severe burn injury. J Burn Care Res. 2006 Jul-Aug;27(4):482-6. doi: 10.1097/01.BCR.0000226018.30433.ED. | |
| 23237822 | Background | Howard TS, Hermann DG, McQuitty AL, Woodson LC, Kramer GC, Herndon DN, Ford PM, Kinsky MP. Burn-induced cardiac dysfunction increases length of stay in pediatric burn patients. J Burn Care Res. 2013 Jul-Aug;34(4):413-9. doi: 10.1097/BCR.0b013e3182685e11. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002056 | Burns |
| D001145 | Arrhythmias, Cardiac |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
Not provided
Not provided
| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| 26729111 | Background | Guillory AN, Clayton RP, Herndon DN, Finnerty CC. Cardiovascular Dysfunction Following Burn Injury: What We Have Learned from Rat and Mouse Models. Int J Mol Sci. 2016 Jan 2;17(1):53. doi: 10.3390/ijms17010053. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |