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The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST) and nerve conduction studies (NCS) were performed with patients with peripheral nerve injury. |
| |
| Controls | Pain-related evoked potentials (PREP) and Quantitative Sensory Testing (QST) were performed with healthy adults. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pain-related evoked potentials (PREP) | Diagnostic Test | PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold. |
|
| Measure | Description | Time Frame |
|---|---|---|
| N1-latency | N1-latency of pain-related evoked potentials in ms | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| N1P1-amplitude | Amplitude of pain-related evoked potentials in µV | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with PNI treated in the university hospital Bergmannsheil Bochum, Bochum, Germany.
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Maier, Prof. Dr. med. | University Hospital Bergmannsheil Bochum | Study Director |
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| ID | Term |
|---|---|
| D059348 | Peripheral Nerve Injuries |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| ID | Term |
|---|---|
| D000092184 | Nerve Conduction Studies |
| ID | Term |
|---|---|
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
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| Quantitative Sensory Testing (QST) | Diagnostic Test | QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain. |
|
| Nerve conduction studies (NCS) | Diagnostic Test | NCS were performed with patients only. |
|
| D014947 | Wounds and Injuries |