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| Name | Class |
|---|---|
| Shenzhen People's Hospital | OTHER |
| Shenzhen Second People's Hospital | OTHER |
| Peking University Shenzhen Hospital | OTHER |
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Conduct a prospective study to detect the change of ctDNA of surgical lung cancer patients.
Studies have shown the feasibility of detecting mutation status by blood circulating tumor DNA (ctDNA) in lung cancer patients.
The investigators plan to test the blood ctDNA in surveillance of surgical lung cancer patients. And evaluate the correlation between ctDNA level with tumor relapse or metastasis.
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| Measure | Description | Time Frame |
|---|---|---|
| Effect of surgery on ctDNA of lung cancer patients | Changes of blood ctDNA of lung cancer patients before and after surgery. | before surgery and 7days after surgery |
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Inclusion Criteria:
Aged 18 to 80 years Undergo radical surgery Histologically confirmed diagnosis of lung cancer Considered primary lung cancer by clinical criteria Patients must have given written informed consent
Exclusion Criteria:
Unable to comply with the study procedure Malignant tumor history Patients who received any treatment prior to resection Unqualified blood samples
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Surgical lung cancer patients.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chaoyu Liu, PhD | Contact | +8675588858978-808 | lcy@genehe.com | |
| Xiaohua Li, PhD | Contact | +8675588858978-808 | lixiaohua@genehe.com |
| Name | Affiliation | Role |
|---|---|---|
| Geng Tian, MD | Shenzhen Second People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shenzhen Second People's Hospital | Recruiting | Shenzhen | Guangdong | 518035 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30981987 | Derived | Peng M, Xie Y, Li X, Qian Y, Tu X, Yao X, Cheng F, Xu F, Kong D, He B, Liu C, Cao F, Yang H, Yu F, Xu C, Tian G. Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA. J Med Genet. 2019 Oct;56(10):647-653. doi: 10.1136/jmedgenet-2018-105825. Epub 2019 Apr 13. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Blood samples and FFPE tissue sections were collected from each patient.
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |