Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| IDRCB | Registry Identifier | 2016-A00333-48 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Epipage 2 (epidemiologic study on small-for-gestational-age children) is a nationwide study implemented to improve our knowledge of the outcome of preterm children in France. This study was launched on March 28, 2011 and includes three groups of preterm children, all born before 35 weeks: extremely preterm infants (born between 22 and 26 completed weeks of gestation), very preterm children (born between 27 and 31 completed weeks) and moderately preterm children (born between 32 and 34 completed weeks).
These children are being studied from their birth up to the age of 12 years. At birth, data on maternal and infants' characteristics were collected from medical records. At one and two years, questionnaires sent to families and to physicians (at two years only) allowed to collect data about the children's life and health.
At five and a half years, medical and psychological assessments are specifically implemented for the study in order to evaluate motor and cognitive disorders in this population.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Medical and neuropsychological assessments | Other | Assessment of health status and development will be performed in specific centers at 5 and a half years. This check-up includes a complete medical examination to look for visual, hearing, motor impairment and health problems, and psychological tests using standardized tools (WPPSI IV ((Wechsler Preschool and Primary Scales Intelligence)) and NEPSY 2 tests) to assess cognitive development of very preterm children. A parental questionnaire will be fulfilled to investigate family's social conditions, maternal health, autism spectrum disorders (Social Communication Questionnaire), the child's quality of life and behavioral development (Strengths and Difficulties Questionnaire). |
| Measure | Description | Time Frame |
|---|---|---|
| Health disorders assessed by medical exam | According to gestational age at birth | 5 years 5 months- 5 years 11 months |
| Motor disorders assessed by medical exam | According to gestational age at birth | 5 years 5 months- 5 years 11 months |
| Cognitive disorders assessed by psychological testing | According to gestational age at birth | 5 years 5 months- 5 years 11 months |
| Behavioural disorders by psychological testing | According to gestational age at birth | 5 years 5 months- 5 years 11 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in medical practices collected by questionnaire | 5 years 5 months- 5 years 11 months | |
| Changes in organization of care collected by questionnaire | 5 years 5 months- 5 years 11 months | |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Preterm children included at birth in the EPIPAGE 2 cohort or in complementary studies whose famillies agree to participate to EPIPAGE 2 follow up (4600 children) + 600 children born at term and participating to the Elfe cohort (French longitudinal study of children)
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hopsitalier d'Agen | Agen | 47000 | France | |||
| CAMSP Albi |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40060937 | Result | Walter-Nicolet E, Marchand-Martin L, Morgan AS, Kaminski M, Benhammou V, Ancel PY, Tourneux P, Pierrat V, Durrmeyer X. Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam: results from the French nationwide EPIPAGE-2 cohort study. Lancet Reg Health Eur. 2025 Feb 18;52:101242. doi: 10.1016/j.lanepe.2025.101242. eCollection 2025 May. | |
| 38408861 |
| Label | URL |
|---|---|
| Epipage 2 website | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
DNA from saliva samples collected from 5 years and a half children
| Set up a DNA Biobank by saliva samples collection |
| 5 years 5 months- 5 years 11 months |
| Albi |
| 82000 |
| France |
| CHU Amiens | Amiens | 80000 | France |
| CHU d'Angers | Angers | 49933 | France |
| CH d'Arras | Arras | 62022 | France |
| CAMSP Auch | Auch | 32000 | France |
| Centre Hospitalier Côte Basque | Bayonne | 64100 | France |
| CH Beauvais | Beauvais | 40319 | France |
| CHU Jean Minjoz | Besançon | 25030 | France |
| Centre Hospitalier de Bordeaux | Bordeaux | 33000 | France |
| CH Bourg en Bresse | Bourg-en-Bresse | 01012 | France |
| CHU de Brest | Brest | 29609 | France |
| Rezo Camsp | Brioude | 43100 | France |
| Hopital Femme, Mère, Enfant | Bron | 69677 | France |
| CHU de Caen | Caen | 14000 | France |
| CH Cahors | Cahors | 46000 | France |
| CMPP de Cahors | Cahors | 46000 | France |
| CH de Calais | Calais | 62107 | France |
| CH de Carcassonne | Carcassonne | 11000 | France |
| CH Castres - Hôpital du pays d'Autan | Castres | 81100 | France |
| CH Chalon sur Saone - William Morey | Chalon-sur-Saône | 71100 | France |
| Réseau Eclaur | Chambéry | 73000 | France |
| CH Métropole Savoie | Chambéry | 73011 | France |
| CAMSP de Charleville Mézières | Charleville-Mézières | 08100 | France |
| CHU Estaing | Clermont-Ferrand | 63000 | France |
| Centre Hospitalier de Colmar | Colmar | 68024 | France |
| CH Compiègne | Compiègne | 60200 | France |
| CH Alpes Leman | Contamine-sur-Arve | 74130 | France |
| CH Sud Francilien | Corbeil | 91106 | France |
| CH Creil | Creil | 60109 | France |
| CAMSP de Dax | Dax | 40100 | France |
| CHU Dijon - Hôpital du Bocage | Dijon | 21079 | France |
| CH de Douai | Douai | 59507 | France |
| CAMSP Espaly | Espaly-Saint-Marcel | 43000 | France |
| SCM Maison de l'enfant | Essey-lès-Nancy | 54270 | France |
| Hôpital d'Epinal | Épinal | 88021 | France |
| Hôpital de Forbach | Forbach | 57600 | France |
| CHU Grenoble / Réseau Naitre et Devenir | Grenoble | 38043 | France |
| Centre Hospitalier de Haguenau | Haguenau | 67500 | France |
| CH Laon | Laon | 02100 | France |
| CHU Le Mans | Le Mans | 72000 | France |
| CH de Lens | Lens | 62307 | France |
| Hôpital Saint Vincent de Paul - Groupement des Hôpitaux de l'Institut Catholique de Lille | Lille | 59000 | France |
| CHRU de Lille | Lille | 59037 | France |
| Hôpital Mère-Enfant de Limoges | Limoges | 87042 | France |
| CAMSP, CHU de Lorient | Lorient | 56100 | France |
| Hopital de la Croix Rousse | Lyon | 69317 | France |
| CHU Hôpital Nord | Marseille | 13015 | France |
| CHU de la Conception | Marseille | 13385 | France |
| CH de Maubeuge | Maubeuge | 59600 | France |
| CH Mâcon | Mâcon | 71000 | France |
| Hôpital de Mercy - CHR Metz Thionville | Metz | 57085 | France |
| CH Annecy Genevois | Metz-Tessy | 74370 | France |
| Centre Hospitalier de Mont de Marsan | Mont-de-Marsan | 40024 | France |
| CAMSP "l'Escabelle" Montauban | Montauban | 82000 | France |
| CH Montauban | Montauban | 82000 | France |
| GHH Havre - Hôpital Jacque Monod | Montivilliers | 76290 | France |
| CHU de Montpellier | Montpellier | 34000 | France |
| CAMSP - CHU Saint-Eloi | Montpellier | 34295 | France |
| Centre Hospitalier de Mulhouse | Mulhouse | 68100 | France |
| CHRU de Nancy (Maternité) | Nancy | 54000 | France |
| CHRU de Nancy (Neuro-pédiatrie) | Nancy | 54000 | France |
| CHU de Nantes | Nantes | 44093 | France |
| CHU Hôpital l'Archet | Nice | 06200 | France |
| CHU de Nimes - Hôpital Caremeau | Nîmes | 30029 | France |
| CHR Orléans | Orléans | 45000 | France |
| Hôpital Armand Trousseau | Paris | 75012 | France |
| CIC Necker | Paris | 75015 | France |
| Centre Hospitalier de Pau | Pau | 64000 | France |
| CHG de Perpignan (CAMSP) | Perpignan | 66046 | France |
| CAMSP de Périgueux | Périgueux | 24016 | France |
| CHU de Reims / CAMSP | Reims | 51100 | France |
| CAMSP, CHU de Rennes | Rennes | 35033 | France |
| CH Rodez - Jacques Puel | Rodez | 12027 | France |
| CH de Roubaix | Roubaix | 59100 | France |
| CHU de Rouen - Pavillon Mère et enfant | Rouen | 76000 | France |
| CAMSP de Saint Brieuc | Saint-Brieuc | 22027 | France |
| CHU Sud Réunion | Saint-Pierre | 97448 | France |
| CHU St Etienne / Réseau HELENA | Saint-Priest-en-Jarez | 42270 | France |
| CH Saint Quentin | Saint-Quentin | 02100 | France |
| Centre Hospitalier Hautepierre | Strasbourg | 67200 | France |
| CH de Bigorre | Tarbes | 65000 | France |
| CAMSP Thionville | Thionville | 57100 | France |
| Hôpital Bel Air Thionville - CHR Metz Thionville | Thionville | 57100 | France |
| CHU de Toulouse - Hôpital des enfants | Toulouse | 31059 | France |
| Clinique Ambroise Paré | Toulouse | 31082 | France |
| CHRU de Tours -Hôpital Clocheville | Tours | 37044 | France |
| CAMSP de Troyes | Troyes | 10000 | France |
| CH Valence | Valence | 26000 | France |
| CH de Valenciennes | Valenciennes | 59322 | France |
| CH de Vannes | Vannes | 56000 | France |
| CH Villefranche sur Saone | Villefranche-sur-Saône | 69655 | France |
| CH Andrée Rosemon | Cayenne | French Guiana |
| CH de l'Ouest Guyanais | Saint-Laurent-du-Maroni | French Guiana |
| CAMSP Basse-Terre | Basse-Terre | Guadeloupe |
| CHU Pointre à Pitre | Les Abymes | Guadeloupe |
| CAMSP Nord-ASFA Sainte Clotilde | Saint-Denis | Reunion |
| CHU Felix Guyon | Saint-Denis | Reunion |
| Result |
| Guellec I, Brunet A, Lapillonne A, Taine M, Torchin H, Favrais G, Gascoin G, Simon L, Heude B, Scherdel P, Kayem G, Delorme P, Jarreau PH, Ancel PY. Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort. Arch Dis Child. 2024 May 17;109(6):503-509. doi: 10.1136/archdischild-2023-326336. |
| 42262600 | Derived | Coignard M, Marchand-Martin L, Kermorvant-Duchemin E, Cambonie G, Tosello B, Ancel PY, Torchin H, Guellec I. School-age neurodevelopmental outcomes after non-emergency red blood cell transfusions in preterm infants: a propensity score-matched study from the Epipage 2 cohort. Eur J Pediatr. 2026 Jun 9;185(7):482. doi: 10.1007/s00431-026-07137-5. |
| ID | Term |
|---|---|
| D002658 | Developmental Disabilities |
| ID | Term |
|---|---|
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided