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Although propofol is widely used as an induction agent for a general anesthesia, it can induce a profound hypotension, which leads to the hypo-perfusion of end organs and eventually increases morbidities. Theoretically, applying Trendelenburg position (head down and leg up position) increases cardiac preloads and cardiac outputs. However, in past researches, changing to Trendelenburg position alone is not enough and does not prevent propofol induced hypotension. Previous studies proved that leg wrapping effectively prevent hypotension after neuraxial anesthesia during Cesarean section. The leg wrapping prevents hypotension by increasing vascular resistance of lower extremities. The investigators made a hypothesis that applying both Trendelenburg position and leg wrapping prevent propofol induced hypotension more effectively than either applying Trendelenburg position only or taking no preventive measures.
** Study procedure
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | leg wrapping without tension & maintain supine position
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| Trendelenburg only | Experimental | leg wrapping without tension & apply Trendelenburg position
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| Trendelenburg & leg wrapping | Experimental | leg wrapping with tension & apply Trendelenburg position
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| leg wrapping with tension | Device |
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| Measure | Description | Time Frame |
|---|---|---|
| SBP_2 | systolic blood pressure at 2 minutes from propofol injection | 2 minutes from propofol injection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyungmook Lee, Dr. | Contact | 82-02-2258-6150 | warmy0828@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| MiHyun Kim, Dr. PhD. | Department of anesthesia and pain medicine, Seoul St. Mary's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St. Mary's Hospital | Recruiting | Seoul | Seo-Cho Gu | 06591 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15281537 | Background | Sun HL, Ling QD, Sun WZ, Wu RS, Wu TJ, Wang SC, Chien CC. Lower limb wrapping prevents hypotension, but not hypothermia or shivering, after the introduction of epidural anesthesia for cesarean delivery. Anesth Analg. 2004 Jul;99(1):241-245. doi: 10.1213/01.ANE.0000121346.33443.5A. | |
| 12553383 | Background | Reuter DA, Felbinger TW, Schmidt C, Moerstedt K, Kilger E, Lamm P, Goetz AE. Trendelenburg positioning after cardiac surgery: effects on intrathoracic blood volume index and cardiac performance. Eur J Anaesthesiol. 2003 Jan;20(1):17-20. doi: 10.1017/s0265021503000036. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D018475 | Head-Down Tilt |
| D016683 | Supine Position |
| ID | Term |
|---|---|
| D011187 | Posture |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Trendelenburg position | Procedure |
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| leg wrapping without tension | Device |
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| supine position | Procedure | 1.maintain supine position |
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