Rudolph: Nasal Microbiota With Red and Sore Nose

RUDOLPH Study Nasal Microbiota and Concurrent Nose Soreness Associated With Common Cold Infection - a Pilot Using the HRV-16 Challenge Model in Healthy Subjects

This pilot study will utilize the experimental rhinovirus infection model to study changes in skin microbiota in relation to skin erythema and soreness.

Inclusion Criteria:

• self reported proneness to developing symptoms of nose redness and/or soreness
• sero-negative to HRV-16 at screening

Exclusion Criteria:

• confirmed or self-reported allergic rhinitis
• history of nasal or otologic surgery
• use of anti-inflammatory medication, recent antibiotics or anti-histamines