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Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Furosemide | Experimental | Single dose of furosemide 1.5 mg/kg intravenously will be given to all participants at 3 hours post-reperfusion of kidney allograft. Urine output will be recorded hourly for 6 hours. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Furosemide Injection | Drug | Furosemide 1.5 mg/kg intravenously at 3 hours post-reperfusion of kidney allograft |
|
| Measure | Description | Time Frame |
|---|---|---|
| Urine output | Urine output per hour (milliliters/hour) after furosemide injection | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Delayed graft function | Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no) | 7 days |
| Creatinine reduction ratio | Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Suwasin udomkarnjananun, M.D. | Contact | 66899679885 | suwasin.u@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| suwasin udomkarnjananun, M.D. | King Chulalongkorn Memorial Hospital and Chulalongkorn University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King Chulalongkorn Memorial Hospital | Recruiting | Bangkok | 10330 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30636249 | Derived | Udomkarnjananun S, Townamchai N, Iampenkhae K, Petchlorlian A, Srisawat N, Katavetin P, Sutherasan M, Santingamkun A, Praditpornsilpa K, Eiam-Ong S, Avihingsanon Y. Furosemide Stress Test as a Predicting Biomarker for Delayed Graft Function in Kidney Transplantation. Nephron. 2019;141(4):236-248. doi: 10.1159/000495765. Epub 2019 Jan 11. |
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| ID | Term |
|---|---|
| D051799 | Delayed Graft Function |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D005665 | Furosemide |
| ID | Term |
|---|---|
| D013424 | Sulfanilamides |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
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| At postoperative day 0,7 and 14 |
| D000814 |
| Aniline Compounds |
| D000588 | Amines |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |