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This is a feasibility study investigating the use of a fluorescently conjugated lectin to identify colorectal dysplasia and cancer during colonoscopy and surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fluorescent Lectin Application | Experimental | Fluorescein conjugated wisteria floribunda will be sprayed onto the colonic surface during colonoscopy or TEM surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fluorescent Lectin Application | Drug | Fluorescein conjugated wisteria floribunda (a lectin). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Signal to background ratios of identified colonic lesions under white light and under fluorescence | This outcome measure compares the fluorescence signal of lesions identified during colonoscopy. | During procedure |
| Number of dysplastic and cancerous lesions identified under white light and under fluorescence | Number of lesions identified under white light colonoscopy will be compared to the number of lesions identified under fluorescence. | During procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Number of dysplastic and cancerous lesions identified under white light and fluorescence in different subgroups | Assessment of subgroups including ulcerative colitis, lesions suspicious of sessile serrated adenomas / traditional serrated adenomas | 12 months |
| Resection margin of of lesions undergoing TEMS resection under white light and under fluorescence. |
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Inclusion Criteria:
Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thomas Barnes | Oxford | Oxfordshire | OX3 7LE | United Kingdom | ||
| Oxford University Hospitals NHS Foundation Trust |
To be confirmed
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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Planned resection margins will be compared under white light and under fluorescence. R0/R1 resection rates will be assessed post operatively. |
| 12 months |
| Oxford |
| Oxfordshire |
| OX3 9DS |
| United Kingdom |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |