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| ID | Type | Description | Link |
|---|---|---|---|
| 1R41AG053120-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| 1st Playable Productions | OTHER |
| Albany Medical College | OTHER |
| Skidmore College | OTHER |
| University of Illinois at Urbana-Champaign |
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This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise. In particular, this study will investigate the possible benefits of physical exercise (such as pedaling an under-table stationary elliptical) or mental exercise (such as playing a videogame on a portable tablet), or combining these activities together (as in the iPACES™ exergame).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| physical, cognitive, then interactive | Active Comparator | physical exercise alone (PES) first, then iPACES |
|
| cognitive, physical, then interactive | Active Comparator | cognitive exercise alone (iCE) first, then iPACES |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physical exercise alone (PES) first | Behavioral | following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week physical exercise-only intervention, then 2-week cognitive exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise) |
| Measure | Description | Time Frame |
|---|---|---|
| executive function composite score | comprised of scores from Stroop, Trails, and Flanker | change over time from baseline to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| brain-derived neurotrophic factor (BDNF) | change in amount in saliva sample over time (pg/ml) per ELISA | change over time from baseline to 3 months |
| Sit-Stand Test | scored performance on time and technique to move from sitting on floor to standing |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cay Anderson-Hanley, PhD | Union College | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Healthy Aging & Neuropsychology Lab @ Union College | Schenectady | New York | 12308 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30200183 | Result | Wall K, Stark J, Schillaci A, Saulnier ET, McLaren E, Striegnitz K, Cohen BD, Arciero PJ, Kramer AF, Anderson-Hanley C. The Enhanced Interactive Physical and Cognitive Exercise System (iPACESTM v2.0): Pilot Clinical Trial of an In-Home iPad-Based Neuro-Exergame for Mild Cognitive Impairment (MCI). J Clin Med. 2018 Aug 30;7(9):249. doi: 10.3390/jcm7090249. | |
| 30233154 | Result | Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clin Interv Aging. 2018 Sep 4;13:1565-1577. doi: 10.2147/CIA.S160756. eCollection 2018. |
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| OTHER |
| National Institute on Aging (NIA) | NIH |
Crossover RCT: participants are randomly assigned to start with one form of intervention and then crossover to another form of the intervention.
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|
| cognitive exercise alone (iCE) first | Device | following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise) |
|
|
| interactive Physical and Cognitive Exercise (iPACES™) | Device | following 2-week placebo for all participants, participants in this arm will then start their active intervention with a randomly assigned 2-week cognitive exercise-only intervention, then 2-week physical exercise-only intervention, then 2-week and 3 month intervals of iPACES™ (interactive physical and cognitive exercise) |
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| change over time in score from baseline to 3 months |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D060825 | Cognitive Dysfunction |
| D019965 | Neurocognitive Disorders |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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