The Relationship Between Vitamin D and Hepatitis B Virus Replication

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

149 HBV carriers with inadequate serum vitamin D levels were randomized to two groups: one is supplied with vitamin D and another without as controls. The markers of HBV replication were compared before and after treatment.

This is a randomized case-control trial. A total of 149 HBV carriers with inadequate vitamin D (< 30 ng/mL) level were enrolled. They were randomly divided to two groups: one group receiving vitamin D supplement (1600 IU/day) for 2 months and another group as controls. The serum vitamin D, HBV DNA and qHBsAg levels were measured at baseline and after vitamin D supplement. Whether HBV DNA and qHBsAg have significant change after vitamin D supplement can be determined.

Inclusion Criteria:

• >20 y/o, HBV carrier
• serum vitamin D < 30ng/ml

Exclusion Criteria:

• Other known causes of hepatitis