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| Name | Class |
|---|---|
| MedStar National Rehabilitation Network | OTHER |
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This study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke. Participants will receive stimulation to each of 3 different brain areas combined with a session of arm exercise.
Small improvements in affected arm movement can be made with intensive physical practice. These improvements could potentially be enhanced by combining non-invasive brain stimulation with practice.
To develop such an intervention, it is necessary to understand which brain areas should be stimulated in which types of patients. It is probably more beneficial to target one side of the brain vs. the other, for example, depending on the characteristics of the stroke.
This study will examine the effect of stimulating one side of the brain vs. the other on the amount of improvement that occurs from physically practicing functional arm movements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Unaffected Hemisphere | Experimental | Application of "Unaffected Transcranial Magnetic Stimulation" to unaffected hemisphere site prior to physical practice |
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| Affected Hemisphere | Experimental | Application of "Affected Transcranial Magnetic Stimulation" to affected hemisphere site prior to physical practice |
|
| Control Site | Active Comparator | Application of "Control Transcranial Magnetic Stimulation" to control site prior to practice |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Unaffected Transcranial Magnetic Stimulation | Procedure | Non-invasive brain stimulation to unaffected hemisphere site prior to practice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in movement time | Percentage change in time it takes to move the arm a standardized distance | Baseline and 1 Day |
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximum reaching distance | Percentage change in maximum distance participant is able to reach | Baseline and 1 Day |
| Change in hand path kinematics | Percentage change in temporal and spatial movement of the hand during reaching |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michelle Harris-Love, PhD | George Mason University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MedStar National Rehabilitation Hospital | Washington D.C. | District of Columbia | 20010 | United States |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D010291 | Paresis |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Each participant will receive stimulation targeting each brain area. The order in which the stimulation sites are targeted for each participant is randomized and there is a washout period of several weeks between each treatment.
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The individual that conducts the tests of arm movement will be unaware of which brain area was stimulated.
| Affected Transcranial Magnetic Stimulation | Procedure | Non-invasive brain stimulation to affected hemisphere site prior to practice |
|
| Control Transcranial Magnetic Stimulation | Procedure | Non-invasive brain stimulation to control site prior to practice |
|
| Baseline and 1 Day |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |