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Monosialoganglioside Ganglioside in Cerebral Radiation Necrosis
A prospective phase II trial was conducted to test the efficacy of monosialoganglioside ganglioside for the treatment of cerebral radiation necrosis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulsed steroid | Active Comparator | Pulse steroid, methylprednisolone, was administered by intravenous infusion over 3 consecutive days. Three grams of methylprednisolone was given in each cycle. Administration of 1 g was infused over 1 h daily for 3 days on an in-patient basis, which then tailed off in 10 days with administration of oral prednisolone. |
|
| Monosialoganglioside ganglioside | Experimental | Monosialoganglioside ganglioside was given at 100 mg/time, once a day for 2 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Monosialoganglioside Ganglioside | Drug | Monosialoganglioside ganglioside was given at 100 mg/time, once a day for 2 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Objective response rate | Response Evaluation Criteria in Solid Tumors (RECIST) were used. | From the first day of treatment, to 3 months after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiaozhong Chen | Recruiting | Hangzhou | Zhejiang | 310022 | China |
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| ID | Term |
|---|---|
| D005677 | G(M1) Ganglioside |
| D008775 | Methylprednisolone |
| D011239 | Prednisolone |
| ID | Term |
|---|---|
| D005732 | Gangliosides |
| D020384 | Acidic Glycosphingolipids |
| D006028 | Glycosphingolipids |
| D006017 | Glycolipids |
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| Methylprednisolone (Steroid Hormone) | Drug | Pulse steroid, methylprednisolone, was administered by intravenous infusion over 3 consecutive days. Three grams of methylprednisolone was given in each cycle. Administration of 1 g was infused over 1 h daily for 3 days on an in-patient basis, which then tailed off in 10 days with administration of oral prednisolone. |
|
| Prednisolone | Drug |
|
| D006001 |
| Glycoconjugates |
| D002241 | Carbohydrates |
| D008055 | Lipids |
| D013107 | Sphingolipids |
| D008563 | Membrane Lipids |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |