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| Name | Class |
|---|---|
| University Hospital, Bordeaux | OTHER |
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Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet membrane electric potential.
Islet quality control after pancreatic islets isolation process is insufficient. The Islet Chip study proposes to develop a bio-sensor that will allow a multi-parametric analysis of islet graft based on measurement of islet membrane electric potential.
The project aims to :
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| Measure | Description | Time Frame |
|---|---|---|
| Beta-score | Beta-score in continuous variable, using the last Beta-score known before the second islet graft. Beta-score is a composite score that reflects pancreatic islet graft function after transplantation and measured from the following criteria: severe hypoglycemia, HbA1c, stimulated C-peptide, fasting glucose, insulin dose or oral diabetes, glycemic variability. | 6 months in average before second islet graft |
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Inclusion Criteria:
Exclusion Criteria:
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Patients enrolled in STABILOT Pancreatic Islet cell graft protocol and willing to participate to ISLET CHIP
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sandrine LABLANCHE, MD, PhD | Contact | +33 4 76 63 54 26 | SLablanche@chu-grenoble.fr | |
| Myriam HADDOUCHE | Contact | +33476766983 | MHaddouche@chu-grenoble.fr |
| Name | Affiliation | Role |
|---|---|---|
| Sandrine LABLANCHE, MD, PhD | University Hospital, Grenoble | Principal Investigator |
| Bogdan CATARGI, MD, PhD | University Hospital, Bordeaux | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Besançon University Hospital | Recruiting | Besançon | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18524662 | Background | Kusnik-Joinville O, Weill A, Salanave B, Ricordeau P, Allemand H. Prevalence and treatment of diabetes in France: trends between 2000 and 2005. Diabetes Metab. 2008 Jun;34(3):266-72. doi: 10.1016/j.diabet.2008.01.005. Epub 2008 Jun 3. | |
| 23897173 | Background | Gruessner RW, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol. 2013 Sep;9(9):555-62. doi: 10.1038/nrendo.2013.138. Epub 2013 Jul 30. |
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pancreatic islet cells
| Clermont Ferrand University hospital | Not yet recruiting | Clermont-Ferrand | France |
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| Grenoble University Hospital | Recruiting | Grenoble | 38000 | France |
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| Lyon University Hospital | Recruiting | Lyon | 69000 | France |
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| Montpellier University Hospital | Recruiting | Montpellier | 34000 | France |
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| Nancy University hospital | Not yet recruiting | Nancy | 54511 | France |
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| University hospital of Strasbourg | Recruiting | Strasbourg | 67000 | France |
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| Geneva University Hospital | Active, not recruiting | Geneva | CH-1211 | Switzerland |
| 3288530 | Background | Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes. 1988 Apr;37(4):413-20. doi: 10.2337/diab.37.4.413. |
| 26068866 | Background | Lablanche S, Borot S, Wojtusciszyn A, Bayle F, Tetaz R, Badet L, Thivolet C, Morelon E, Frimat L, Penfornis A, Kessler L, Brault C, Colin C, Tauveron I, Bosco D, Berney T, Benhamou PY; GRAGIL Network. Five-Year Metabolic, Functional, and Safety Results of Patients With Type 1 Diabetes Transplanted With Allogenic Islets Within the Swiss-French GRAGIL Network. Diabetes Care. 2015 Sep;38(9):1714-22. doi: 10.2337/dc15-0094. Epub 2015 Jun 11. |
| 25788295 | Background | Lebreton F, Pirog A, Belouah I, Bosco D, Berney T, Meda P, Bornat Y, Catargi B, Renaud S, Raoux M, Lang J. Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells. Diabetologia. 2015 Jun;58(6):1291-9. doi: 10.1007/s00125-015-3558-z. Epub 2015 Mar 19. |
| 24838208 | Background | Renaud S, Catargi B, Lang J. Biosensors in diabetes : how to get the most out of evolution and transpose it into a signal. IEEE Pulse. 2014 May-Jun;5(3):30-4. doi: 10.1109/MPUL.2014.2309577. |