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In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Experimental | Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Biological | Blood sampling will be performed at inclusion to investigate some biological eligibility criteria, and the day of MRI in order to analyse fibrosis biomarkers and collagen synthesis biomarkers |
| Measure | Description | Time Frame |
|---|---|---|
| Regional myocardial strain | Segmental measures of systolic and diastolic strains with magnetic resonance imaging (MRI) | The day of MRI |
| Measure | Description | Time Frame |
|---|---|---|
| MRI T1 value | This value is an indicator of interstitial fibrosis and extracellular volume | The day of MRI, before gadolinium injection |
| MRI T1 value | Diminution of this value after gadolinium injection is an indicator of increasing quantity of interstitial fibrosis and extracellular volume |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre CROISILLE, MD, PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Département de Radiologie, CHU Saint-Etienne - Hôpital Nord | Saint-Etienne | 42270 | France |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| MRI | Device | MRI will be performed to measure interstitial fibrosis |
|
| Skin auto-fluorescence | Biological | Skin auto-fluorescence measures will be performed to measure advanced glycation end-products (AGE) produced by collagen degradation |
|
| The day of MRI, 15 minutes after gadolinium injection |
| Apparent Diffusion Coefficient (ADC) with MRI | ADC is measured with diffusion weighted imaging | The day of MRI |
| Blood carboxy-terminal propeptide of procollagen type I (PICP) rate | Collagen blood biomarker analysis | The day of MRI |
| Blood amino-terminal propeptide of procollagen type III (PIIINP) rate | Collagen blood biomarker analysis | The day of MRI |
| Advanced Glycation End-products (AGE) rate | Skin auto-fluorescence AGE measures | The day of MRI |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |