A Randomized, Open-Label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared With Topotecan for Subjects With Advanced or Metastatic DLL3high Small Cell Lung Cancer (SCLC) Who Have First Disease Progression During or Following Front-Line Platinum-Based Chemotherapy (TAHOE)
A Randomized, Open-Label, Multicenter, Phase 3 Study of Rovalpituzumab Tesirine Compared With Topotecan for Subjects With Advanced or Metastatic DLL3high Small Cell Lung Cancer (SCLC) Who Have First Disease Progression During or Following Front-Line Platinum-Based Chemotherapy (TAHOE)
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy.
Inclusion Criteria:
Exclusion Criteria:
Sacramento, California 95817, United States
Jacksonville, Florida 32256, United States
Meridian, Idaho 83712, United States
Evanston, Illinois 60201, United States
Lansing, Michigan 48912, United States
Lesnoy, 223040, Belarus
Passo Fundo, Rio Grande do Sul 99010-080, Brazil
São José do Rio Preto, São Paulo 15090-000, Brazil
Rio de Janeiro, 20231-050, Brazil
Budapest, Pest County 2045, Hungary
Kashiwa-shi, Chiba 277-8577, Japan
Kurume-shi, Fukuoka 830-0011, Japan
Akashi-shi, Hyōgo 673-8558, Japan
Himeji-shi, Hyōgo 670-0012, Japan
Hirakata-shi, Osaka 573-1191, Japan
Osaka-sayama-shi, Osaka 589-8511, Japan
Sunto-gun, Shizuoka 411-8777, Japan
Chuo-ku, Tokyo 104-0045, Japan
Koto-ku, Tokyo 135-8550, Japan
Shinagawa-ku, Tokyo 142-0054, Japan
Matsusaka-shi MIE, 515-8544, Japan
Del. Benito Juárez, 03810, Mexico
Rzeszów, Podkarpackie Voivodeship 35-021, Poland
Moscow, Moscow Oblast 115478, Russia
Daegu, Seoul Teugbyeolsi 41404, South Korea
Seodaemun-gu, Seoul Teugbyeolsi 03722, South Korea
Taipei City, Taipei 100, Taiwan
Taipei City, Taipei 11490, Taiwan
Altindağ, Ankara 06250, Turkey (Türkiye)
Battalgazi/malatya, 44280, Turkey (Türkiye)
Kecioren/ankara, 06280, Turkey (Türkiye)
Zaporizhzhya, Zaporizhzhia Oblast 69040, Ukraine
Kryviy RIH, 50048, Ukraine
Uzhhorod, 88000, Ukraine