Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries. Perfusion index has been considered a useful tool for monitoring changes in peripheral perfusion using Masimo set and serum lactate for central perfusion. Many medications were used to induce hypotension. In this study we will compare the effects of tridil and labetalol on the perfusion.
The purpose of this study to detect the degree of hypotension that helps the surgeon and dosen't impair patient's perfusion and to compare the hypotensive effects of both tridil and labetalol infusions on the perfusion.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nitroglycerin group | Active Comparator | this group will receive nitroglycerin infusion for controlled hypotension.0.5-5ug/kg/min to keep MAP 55-65mmhg then Massimo device will be attached to the patients when MAP reached the desired level |
|
| labetalol group | Active Comparator | this group will receive labetalol infusion fo controlled hypotension 0.4-3mg/kg/hr to keep MAP 55-65mmhg.then Massimo device will be attached to the patients when MAP reached the desired level |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Massimo device | Combination Product | Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI). |
|
| Measure | Description | Time Frame |
|---|---|---|
| perfusion index | perfusion index is an indication of peripheral perfusion | 3hrs |
| serum lactate level | lactate level is an indication of central perfusion | 3hrs |
| Measure | Description | Time Frame |
|---|---|---|
| surgical feild score | isan indication of adequacy of controlled hypotension | 3hrs |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005996 | Nitroglycerin |
| D007741 | Labetalol |
| ID | Term |
|---|---|
| D009574 | Nitro Compounds |
| D009930 | Organic Chemicals |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Nitroglycerin drug | Drug | Nitroglycerin is a drug used as an hypotensive agent through its vasodilation effect on veins |
|
|
| Labetalol | Drug | Labetalol is an antagonist of adrenergic receptors (a1, b1, b2) which is used as an hypotensive inducer. This drug targets the beta receptors 5 to 10 times more specific than alpha receptors so that minor tachycardia happens |
|
|
| D000438 |
| Alcohols |
| D012457 | Salicylamides |
| D000577 | Amides |
| D000588 | Amines |