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Bayesian models of perception represent a promising approach to describe information processing by the brain. Predictive coding hypothesizes a process in which top-down expectations are continuously compared across multiple hierarchical levels with bottom-up sensory inputs and the differences or error signals are propagated in a bottom-up direction. The investigators hypothesize that strong expectations, are best investigated in expert processes such as face and voice recognition in humans. Individuals in complex social systems need to extract socially relevant information in a fast and efficient manner; hence, the majority of humans constitute face, voice and gender experts. Nevertheless, linking such combined abilities to brain activity with regards to the predictive coding hypothesis has not been attempted.Our results suggest asymmetric contributions of visual and auditory signals to the gender classification task. This sensitive psychophysical procedure is implemented in a decoding approach using fMRI and multi-voxel pattern analysis (MVPA). The investigators plan to test whether cortical areas implicated in processing auditory and visual gender signals show similar asymmetries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fMRI study | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI study | Other | Functional brain activations of face-voice processing during a gender task |
|
| Measure | Description | Time Frame |
|---|---|---|
| Identify neural correlates (fMRI) of face / voice interaction in a gender classification task | Classical functional analyses (GLM) and advanced statistical analyses of brain activations (BrainVoyager and Matlab softwares). | Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2). |
| Identify neural correlates (fMRI) of face / voice respective contribution in a gender classification task | Classical functional analyses (GLM) and advanced statistical analyses of brain activations | Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2). |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alain NICOLAS, MD | Le VINATIER | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Le VINATIER | Bron | 69 500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20805488 | Background | Gerardin P, Kourtzi Z, Mamassian P. Prior knowledge of illumination for 3D perception in the human brain. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16309-14. doi: 10.1073/pnas.1006285107. Epub 2010 Aug 30. | |
| 22423089 | Background | Wacongne C, Changeux JP, Dehaene S. A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci. 2012 Mar 14;32(11):3665-78. doi: 10.1523/JNEUROSCI.5003-11.2012. |
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| 25422460 | Background | Pegado F, Comerlato E, Ventura F, Jobert A, Nakamura K, Buiatti M, Ventura P, Dehaene-Lambertz G, Kolinsky R, Morais J, Braga LW, Cohen L, Dehaene S. Timing the impact of literacy on visual processing. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5233-42. doi: 10.1073/pnas.1417347111. Epub 2014 Nov 24. |
| 24179228 | Background | Markov NT, Ercsey-Ravasz M, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H. Cortical high-density counterstream architectures. Science. 2013 Nov 1;342(6158):1238406. doi: 10.1126/science.1238406. |
| 22868568 | Background | Charrier C, Knoblauch K, Maloney LT, Bovik AC, Moorthy AK. Optimizing multiscale SSIM for compression via MLDS. IEEE Trans Image Process. 2012 Dec;21(12):4682-94. doi: 10.1109/TIP.2012.2210723. Epub 2012 Jul 30. |
| 24722563 | Background | Gerardin P, Devinck F, Dojat M, Knoblauch K. Contributions of contour frequency, amplitude, and luminance to the watercolor effect estimated by conjoint measurement. J Vis. 2014 Apr 10;14(4):9. doi: 10.1167/14.4.9. |
| 40670460 | Result | Abbatecola C, Kennedy H, Knoblauch K. Directed attention influences optimality of top-down and bottom-up multi-modal perceptual integration. Sci Rep. 2025 Jul 16;15(1):25742. doi: 10.1038/s41598-025-09542-6. |
| 34122023 | Result | Abbatecola C, Gerardin P, Beneyton K, Kennedy H, Knoblauch K. The Role of Unimodal Feedback Pathways in Gender Perception During Activation of Voice and Face Areas. Front Syst Neurosci. 2021 May 28;15:669256. doi: 10.3389/fnsys.2021.669256. eCollection 2021. |