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The BEST study will investigate the feasibility of cognitive interventions in a randomized, placebo-controlled, clinical trial. The investigators will recruit 45 cognitively normal subjects and engage them in one of three cohorts over an 8 week period, including active reading vs. origami study arms and a placebo group without structured cognitive intervention.
This is a randomized, placebo controlled study investigating the practical implementation and conduct of two cognitive interventions in non-demented subjects. Subjects will be randomized 1:1:1 into three groups including: 1) a Book club that includes weekly one hour meetings and daily reading assignments, 2) Origami lessons (one hour/week) with daily take home Origami activities to complete, and 3) a placebo group with unstructured lifestyle activities (normal lifestyle activities without restraint).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Usual lifestyle activities |
|
| Origami | Experimental | Origami lessons (one hour/week) with daily take home Origami activities to complete |
|
| Reading | Experimental | Daily reading (out loud into a voice recorder) for one hour |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Behavioral | The placebo group will have unstructured lifestyle activities (normal lifestyle activities without restraint). |
|
| Measure | Description | Time Frame |
|---|---|---|
| MOCA | The Montreal Cognitive Assessment (MOCA) measures general cognitive function | 8 weeks |
| FCSRT | The Free and Cued Selective Reminding Test (FCSRT) measures memory function. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to protocol | Objective measures of weekly time devoted to cognitive training activities | 8 weeks |
| Electroencephalogram | resting state electroencephalogram pattern |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gregory A Jicha, MD, PhD | University of Kentucky | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sander's Brown Center on Aging | Lexington | Kentucky | 40536 | United States |
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| Origami | Behavioral | Origami lessons (one hour/week) with daily take home Origami activities to complete |
|
| Reading | Behavioral | Book club that includes weekly one hour meetings and daily reading assignments |
|
| 8 weeks |
| Evoked Related Potential | Evoked Related Potential P300 using the Bluegrass memory task | 8 weeks |