Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The current project will use the Complete Health Improvement Program (CHIP) as an intervention for patients with chronic pain. CHIP is a nationally recognized program that encourages a diet of whole plant-based foods, moderate exercise, stress reduction, and social support. Patients with chronic pain who enroll in CHIP classes will be monitored and compared to patients with chronic pain who are not enrolled in CHIP classes. It is hypothesized that patients who complete CHIP will have increased telomerase activity and longer relative telomere length at follow-up when compared to those who do not enroll in the program. Chromosomes consist of DNA that contains the genetic makeup of an individual; and telomeres are the caps on these chromosomes that protect them from damage. Telomere shortening occurs normally with aging and once they are too short to replicate cellular death occurs. Telomerase is a ribonucleic protein that counterbalances this shortening by extending the ends of chromosomes. Research has shown that patients with chronic pain may have shorter telomeres relative to others of the same age. This study will investigate this association further.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Participants in the Complete Health Improvement Program. |
|
| No Change to Treatment | No Intervention | Participants who choose not to participate in the Complete Health Improvement Program. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The Complete Health Improvement Program | Behavioral | The Complete Health Improvement Program is a nationally recognized program that encourages a diet of whole plant based foods, moderate exercise, stress reduction, and social support. |
| Measure | Description | Time Frame |
|---|---|---|
| Telomerase activity changes as a result of lifestyle change | Assessed via peripheral blood mononuclear cells | Change from baseline telomerase at 3 months |
| Subjective pain ratings as a function of positive lifestyle modifications | Assessed via the Brief Pain Inventory - Short Form. Measures pain intensity from 0 to 10, 10 being pain as bad as you can imagine. Also measures the extent to which pain interferes with daily functioning (0 - 10 possible, with 10 indicating completely interferes). | Change from baseline subjective pain at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Relative telomere length changes as a result of lifestyle change | Assessed via whole blood samples | Change from baseline telomere length at 3 months |
| Relative telomere length changes as a result of lifestyle change at 1-year follow-up |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Katrina Hamilton, M.S. | Ohio University | Principal Investigator |
| David Drozek, D.O. | Ohio University | Study Director |
| Peggy Zoccola, Ph.D. | Ohio University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio University | Athens | Ohio | 45701 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16913218 | Background | Shcherbakova DM, Zvereva ME, Shpanchenko OV, Dontsova OA. [Telomerase: structure and properties of the enzyme, characteristics of the yeast telomerase]. Mol Biol (Mosk). 2006 Jul-Aug;40(4):580-94. Russian. | |
| 11152456 | Background | Li B, Comai L. Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J Biol Chem. 2001 Mar 30;276(13):9896-902. doi: 10.1074/jbc.M008575200. Epub 2001 Jan 4. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Assessed via whole blood samples
| Change from 3 month follow-up data of telomere length at 1-year |
| Fasting glucose changes as a result of lifestyle change | Assessed via whole blood samples | Change from baseline fasting glucose at 3 months |
| Fasting glucose changes as a result of lifestyle change at 1-year follow-up | Assessed via whole blood samples | Change from 3 month follow-up data of fasting glucose at 1-year |
| Fasting lipid profile (i.e., HDL, LDL, triglycerides) modification as a result of lifestyle change | Assessed via whole blood | change from baseline fasting lipids at 3 months |
| Fasting lipid profile (i.e., HDL, LDL, triglycerides) modification as a result of lifestyle change at 1-year follow-up | Assessed via whole blood | Change from 3 month follow-up data of fasting lipids at 1-year |
| C-reactive protein changes as a result of lifestyle change | Assessed via plasma | change from baseline C-reactive protein at 3 months |
| C-reactive protein changes as a result of lifestyle change at 1-year follow-up | Assessed via plasma | Change from 3 month follow-up data of C-reactive protein at 1-year |
| Overall well-being changes as a result of lifestyle change | The RAND-36 item short form survey. High score indicates more favorable health state. Minimum score 0 Maximum score 100. | change from baseline overall well-being at 3 months |
| Overall well-being changes as a result of lifestyle change at 1-year follow-up | The RAND-36 item short form survey. High score indicates more favorable health state. Minimum score 0 Maximum score 100. | Change from 3 month follow-up data of overall well-being at 1-year |
| Perceived Stress changes as a result of lifestyle change | The 14-item Perceived Stress Scale. Minimum score 0 Maximum score 40. Higher scores indicate greater perceived stress. | change from baseline perceived stress at 3 months |
| Perceived Stress changes as a result of lifestyle change at 1-year follow-up | The 14-item Perceived Stress Scale. Minimum score 0 Maximum score 40. Higher scores indicate greater perceived stress. | Change from 3 month follow-up data of perceived stress at 1-year |
| Depressive symptom changes as a result of lifestyle change | Center for Epidemiological Studies Depression Scale. Higher score indicates greater depressed mood. Minimum score 0 Maximum score 60. | change from baseline depressed mood at 3 months |
| Depressive symptom changes as a result of lifestyle change at 1-year follow-up | Center for Epidemiological Studies Depression Scale. Higher score indicates greater depressed mood. Minimum score 0 Maximum score 60. | Change from 3 month follow-up data of depressed mood at 1-year |
| Perceived social support modification as a result of lifestyle change | Multidimensional Scale of Perceived Social Support. Higher score indicates greater perceived social support. Minimum score 1 Maximum score 7. | change from baseline perceived social support at 3 months |
| Perceived social support modification as a result of lifestyle change at 1-year follow-up | Multidimensional Scale of Perceived Social Support. Higher score indicates greater perceived social support. Minimum score 1 Maximum score 7. | Change from 3 month follow-up data of perceived social support at 1-year |
| Health-Promoting behavior change as a result of lifestyle modification | Health-Promoting Lifestyle Profile II questionnaire. Higher score indicate greater health promotion. Minimum score 1 Maximum score 4. | change from baseline health promoting behavior at 3 months |
| Health-Promoting behavior change as a result of lifestyle modification at 1-year follow-up | Health-Promoting Lifestyle Profile II questionnaire. Higher score indicate greater health promotion. Minimum score 1 Maximum score 4. | Change from 3 month follow-up data of health promoting behavior at 1-year |
| Telomerase activity changes as a result of lifestyle change at 1-year follow-up | Assessed via peripheral blood mononuclear cells | Change from 3 month follow-up data of telomerase activity at 1-year |
| Subjective pain ratings as a function of positive lifestyle modifications at 1-year follow-up | Assessed via the Brief Pain Inventory - Short Form. Measures pain intensity from 0 to 10, 10 being pain as bad as you can imagine. Also measures the extent to which pain interferes with daily functioning (0 - 10 possible, with 10 indicating completely interferes). | Change from 3 month follow-up data of subjective pain at 1-year |
| 24527219 | Background | Drozek D, Diehl H, Nakazawa M, Kostohryz T, Morton D, Shubrook JH. Short-term effectiveness of a lifestyle intervention program for reducing selected chronic disease risk factors in individuals living in rural appalachia: a pilot cohort study. Adv Prev Med. 2014;2014:798184. doi: 10.1155/2014/798184. Epub 2014 Jan 16. |
| 23031395 | Background | Hassett AL, Epel E, Clauw DJ, Harris RE, Harte SE, Kairys A, Buyske S, Williams DA. Pain is associated with short leukocyte telomere length in women with fibromyalgia. J Pain. 2012 Oct;13(10):959-69. doi: 10.1016/j.jpain.2012.07.003. |