In this study, the investigators propose to evaluate cognitive function and determine the feasibility of neurocognitive assessment using a select CogState test battery in patients with primary intracranial malignancies receiving photon- or proton-based cranial irradiation with curative intent. The investigators will use the CogState software to quantify changes in verbal learning, memory, and executive function over the initial months and years following radiation treatment. Cognitive changes and temporal patterns of function will be compared to baseline performance for each patient. Data regarding cognitive function, fatigue, quality of life, and standard patient reported outcomes will be collected to characterize the daily impact of treatment. In addition, observed outcomes will be correlated with dosimetry values, radiation dose volumes, and anatomic dose distribution.

Inclusion Criteria:

• Age ≥ 4 years with primary CNS malignancy
• Able to use computer for assessment battery
• Receiving photon- or proton-based radiation for primary intracranial malignancy
• Demonstrates the capacity to sign informed consent

Exclusion Criteria:

• Patients with WHO Grade IV tumors

Patients with primary CNS malignancy