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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00997-32 | Other Identifier | ID-RCB number, ANSM |
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This study evaluates the link between genetic polymorphisms as r7903146, rs12255372 of TCF7L2 gene and the risk of developing hyperglycemia during Intensive care unit stay
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intensive care patients | patients with a least one organ dysfunction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genetic analysis | Genetic |
| ||
| blood and stools samples |
| Measure | Description | Time Frame |
|---|---|---|
| value of the odds ratio associated with the relationship between a polymorphism TCF7L2 gene and the occurrence of hyperglycemia | find a link between genetic polymorphism of TCF7L2 and the risk of developing hyperglycemia in intensive care patients with a least one organ dysfunction. the hyperglycemia is defined fasting glucose> 1.26 g / l twice or need for treatment with insulin) | one year after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in inflammatory markers | one year after inclusion | |
| Changes in serum lipid profile | Changes in cholesterol total, LDL cholesterol, HDL cholesterol and triglycerides | one year after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Blood samples collection | the blood samples collection will created for next research Both on diabetes and / or insulin resistance as its determinisms, at the ICU patient | 5 years |
| Number of patients with genotype TCF7L2 by PCR |
Inclusion Criteria:
Exclusion Criteria:
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patients admitted in ICU > 48h with at least one organ dysfunction
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| Name | Affiliation | Role |
|---|---|---|
| Mercedes Jourdain, MD, PhD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Cote de Nâcre | Caen | France | ||||
| Hôpital Roger Salengro, CHRU de Lille |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31121319 | Result | Ben Hamou A, Kipnis E, Elbaz A, Bignon A, Nseir S, Tamion F, Du Cheyron D, Jaillette E, Voisin B, Robriquet L, Vanbaelinghem C, Thellier D, Abi Rached H, Jannin A, Duhamel A, Behal H, Machuron F, Espiard S, Preiser JC, Preau S, Pattou F, Jourdain M. Association of transcription factor 7-like 2 gene (TCF7L2) polymorphisms with stress-related hyperglycaemia (SRH) in intensive care and resulting outcomes: The READIAB study. Diabetes Metab. 2020 Jun;46(3):243-247. doi: 10.1016/j.diabet.2019.05.001. Epub 2019 May 20. |
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blood, plasma, mononuclear cells, DNA
| Biological |
|
| Changes in liver enzymes | Changes in total alanine transaminase (ALT) total gamma-GT total aspartate transaminase (AST) | one year after inclusion |
| Insulin Resistance (HOMA) | Calculated using the updated homeostasis model assessment (HOMA) calculator.Higher numbers indicate higher insulin resistance. There are no established cutoffs indicating impaired resistance. | one year after inclusion |
the prevalence of TCF7L2, in the intensive care patient or not glycemic control, and compared to the values found in the general population.
the TCF7L2 genes will be evaluated by the Taqman method (7900HT Fast Real-Time PCR System-Applied BioSystem).
| 5 years |
| Lille |
| France |
| CH Victor Provot | Roubaix | France |
| CHU Charles Nicolle | Rouen | France |
| CH Tourcoing | Tourcoing | France |
| ID | Term |
|---|---|
| D020022 | Genetic Predisposition to Disease |
| D006943 | Hyperglycemia |
| D009102 | Multiple Organ Failure |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D012769 | Shock |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D005820 | Genetic Testing |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D005821 | Genetic Techniques |
| D033142 | Genetic Services |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D003954 | Diagnostic Services |
| D011314 | Preventive Health Services |
| D013048 | Specimen Handling |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
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