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| Name | Class |
|---|---|
| Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna | OTHER |
| The University of Queensland | OTHER |
| Ministry of Health, Italy | OTHER_GOV |
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In hemiplegia quantitatively measurement of the asymmetry in the use of upper limbs could overcome the limitation of many outcome measures in which scores are dependent on the experience and training of the therapist. The main aim of this study was to determine the validity of Actigraph GXT3+ to measure asymmetry in the use of the two upper limbs during the Assisting Hand Assessment (AHA) in children, adolescents and young with hemiplegia aged 5-19 years, compared to age-matched typically developing subjects (TD).
This study aims to validate the use of Actigraphs as an evaluation tool of the upper limb asymmetry in children / adolescents and young adults with typical development or hemiplegia.
The validation involves two stages:
The first stage, carried out in the clinical setting, provides the use of Actigraphs (Actigraph GXT3+ and in a subgroup also FitBit) during the administration of clinical tests which are usually performed for the evaluation of the manual dominance in individuals with hemiplegia but also suitable for those with typical development.
This first phase will allow to compare the quantitative measures acquired by the actigraphs (e.g. the mean activity of each hand and the asymmetry index i.e. difference between the mean activities of the two arms) with those from clinical standardized measures.
The second phase, carried out in a non-clinical setting, provides the use of Actigraphs (Actigraph GXT3+ and in a subgroup also FitBit) in a subgroup of subject involved in the first phase for a week in order to measure the asymmetry index during the activities of daily living.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Children, Adolescents and Young with hemiplegia |
| |
| Control group | Children, Adolescents and Young with typical development |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Actigraph | Other | Actigraphs worn on wrists |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Asymmetry Index (AI) and Assisting Hand Assessment (AHA) scores. | The asymmetry index (AI) is the difference between the mean activities of the dominant with those of the non dominant hand and it will be correlated with the scores of AHA. The AHA measures Upper Limb function during bimanual activities. The test evaluates spontaneous use of assisting hand during a semi-structured 10-15 minutes session with specific toys (Kids-AHA) or tasks (Ad-AHA) requiring bimanual handling. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between AI during AHA and AI in 7 days | Correlation of AI between a standardized bimanual test with 7 days of common daily life | Baseline- 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Box and Block test (BBT) and mean activity of dominant and non dominant hand | The mean activity of each hand will be correlated with the BBT that measures unilateral gross manual dexterity. It is a quick (2-5 minutes), simple and inexpensive test. It can be used with a wide range of populations from childhood to adulthood. | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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Children, Adolescents and Adults with hemiplegia and age-matched controls with typical development
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| Name | Affiliation | Role |
|---|---|---|
| Giuseppina Sgandurra, MD, PhD | IRCCS Fondazione Stella Maris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Stella Maris Foundation | Calambrone | Pisa | 56128 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21652563 | Background | Martin JL, Hakim AD. Wrist actigraphy. Chest. 2011 Jun;139(6):1514-1527. doi: 10.1378/chest.10-1872. | |
| 8647035 | Background | Nagels G, Marion P, Pickut BA, Timmermans L, De Deyn PP. Actigraphic evaluation of handedness. Electroencephalogr Clin Neurophysiol. 1996 Jun;101(3):226-32. doi: 10.1016/0924-980x(96)95566-6. |
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| ID | Term |
|---|---|
| D006429 | Hemiplegia |
| ID | Term |
|---|---|
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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| Correlation among Mean activity and asymmetry index during standardized clinical activities. | The mean activity of each hand and the asymmetry index will be analyzed during some other activities such as Writing, Upper Limb Physician's Rating Scale, Six Minutes Walking Test, Rest Supine Position | Baseline |
| 40181251 | Derived | Beani E, de 'Cavalieri MF, Filogna S, Barzacchi V, Cianchetti M, Maselli M, Martini G, Menici V, Prencipe G, Sicola E, Cioni G, Sgandurra G. Wearable sensors for measuring spontaneous upper limb use in children with unilateral cerebral palsy and typical development. J Neuroeng Rehabil. 2025 Apr 3;22(1):71. doi: 10.1186/s12984-025-01601-3. |
| 30795810 | Derived | Beani E, Maselli M, Sicola E, Perazza S, Cecchi F, Dario P, Braito I, Boyd R, Cioni G, Sgandurra G. Actigraph assessment for measuring upper limb activity in unilateral cerebral palsy. J Neuroeng Rehabil. 2019 Feb 22;16(1):30. doi: 10.1186/s12984-019-0499-7. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |