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With change of personnel and lab resources, this study was not feasible without independent funding
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The investigators are interested about the degree to which individuals can persist with individualized treatment goals when their cues (external such as food, or internal such as anxiety) are high for impulsive/maladaptive behavior (e.g., purging, not eating, etc.). The investigators want to find specific high-difficulty situations in which to assess whether participants remain mindful of the big picture and are willing to work toward therapeutic goals. Also, the investigators want to rate the participants degree of success (e.g., proportion of calories eaten) assessed more objectively.
The theory is that working memory capacity (WMC) modulates the ability to keep longer-term goals in mind when faced by current stress/temptations. For example, the ability to control drinking when one has an implicit urge to drink is predicted by WMC. The ability to apply a novel emotional regulation skill at a time of stress is also predicted by WMC. Indeed, the generic ability to pursue goals in the future (as assessed by the discounting of the value of future goals) is reliably predicted by WMC. There is also evidence that activation of brain regions associated with WMC (by direct activation of the dorsolateral prefrontal cortex via transcranial magnetic stimulation (TMS), or by having a person complete a relevant cognitive task) improves delay discounting.
Accordingly, the investigators are proposing a study that both assesses the link between WMC and relevant the clinical measures noted above, as well as changes in these measures following activation of WM with a cognitive prime (WM task). The overall design calls for an initial WMC assessment, followed by randomization to complete 3 days of a WM prime and then 3 days of a no prime group, or vice versa. The investigators then assess the clinical outcomes noted above across the following 6 days, with a WM prime first or no prime first occurring prior to the targeted behaviors. The investigators will prime WM prior to participant's evening meal, with the WM intervention offered during the free time before this meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Working Memory Intervention (N-back) | Experimental | Participants will complete the working memory priming task either for the first 3 days of the intervention or the last 3 days of the intervention, with order counterbalanced across participants. The working memory prime is the N-back test, a measure of working memory in which individuals need to make a response to targets which are repeated letters either in a row (i.e., one-back) or in every-other-letter format (i.e., two-back) (Jaeggi et al., 2010). |
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| "White Bear" Task | Placebo Comparator | Participants will complete this non-working-memory control task either for the first 3 days of the intervention or the last 3 days of the intervention, depending on counterbalanced order. The task consists of a procedure developed by Wegner and colleagues (1987) in a study of thought suppression, which instructs participants to inhibit thoughts of a white bear, and to indicate with a pencil mark every time the thought of the white bear occurs to them. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| N-back | Behavioral | The N-back task is a measure of working memory in which individuals need to make a response to targets which are repeated letters either in a row (i.e., one-back) or in every-other-letter format (i.e., two-back). |
| Measure | Description | Time Frame |
|---|---|---|
| Meal Compliance | Therapeutic Food and Snack Log. | Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |
| Measure | Description | Time Frame |
|---|---|---|
| Mood | Mood Monitoring Form | Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |
| Delay Discounting | Monetary-Choice Questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
None
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Boston University | Boston | Massachusetts | 02215 | United States |
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| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
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| White Bear Task | Behavioral | For this thought suppression task, participants are instructed to inhibit thoughts of a white bear, and to indicate with a pencil mark every time the thought of the white bear occurs to them. |
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| Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |
| Eating Disorder Symptoms | Eating Disorder Diagnostic Scale (EDDS) | Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |
| Depression | Center for Epidemiologic Studies Depression Scale (CES-D) | Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |
| Depression, Anxiety, and Stress | Depression Anxiety Stress Scales (DASS-21) | Comparison of day 5 to day 8 scores taking into account intervention type, intervention order, and baseline scores |