The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure

The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function

Random grouping by computer, divided into two groups, a group of rhubarb treatment group, another group for the placebo group.

Patients were randomly divided into two groups, using rhubarb powder or placebo. Rhubarb is commercially certified rhubarb(Rheum palmatum, Sichuan origin, provided by the pharmacy of my hospital), ground into a powder, over 80 mesh steel mesh, Two days before 6g, three times / day, oral or nasal feeding, two days later reduced to 3g, three times / day, oral or nasal feeding; Another group of patients taking placebo, with the same dose of Rhubarb; The overall course of the two drugs was a week.

Inclusion Criteria:

1. Age:18-65 year old;
2. Diagnosis: sepsis with gastrointestinal dysfunction (II-III grade AGI); gastrointestinal dysfunction after trauma (II-III AGI);
3. Complete gastrointestinal tract anatomic structure（including the ileum and colon stoma）

Exclusion Criteria:

1. Hemodynamic instability;
2. Underlying diseases: cardiac function III~IV, chronic liver dysfunction Child-Pugh score >9 points;
3. Less than 5 days after surgery for stomach and small intestine，less than 7 days after Colonic surgery, Postoperative gastrointestinal leakage;
4. Abdominal Compartment Syndrome;
5. mechanical ileus
6. active gastrointestinal hemorrhage