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This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be randomly divided into three groups. Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.
Intravenous volume replacement alter the dynamics of microcirculation. Perfusion index and pulse variability index are the recent parameters to evaluate the tissue microcirculatory condition. This study is aimed to assess the effects of intravenously administered three fluid types on perfusion index and pulse variability index in patients during preoperative period. Patients will be taken to recovery room in the operating theatre and wait for 15 minutes to balance the skin temperature of the patients to the environment. Patients will be randomly divided into three groups using closed envelope technique as Group L (received 500 ml of Ringer's lactate), Group S (500 ml of saline) and Group H (received 500 ml of 6% hydroxyethylstarch). Baseline, 5th, 10th, 15th, 20th, 25th and 30th min non-invasive blood pressure, oxygen saturation, heart rate, room temperature, perfusion index and pulse variability index will be measured and recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sodium chloride | Active Comparator | 0.9% isotonic sodium chloride, 500 ml, one package in 30 minutes |
|
| Hydroxyethylstarch | Active Comparator | 6% hydroxyethylstarch, 500 ml, one package in 30 minutes |
|
| Ringer-Lactate Infusion Solution Bag | Active Comparator | Ringer's lactate, 500 ml, one package in 30 minutes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sodium chloride | Drug | 500 ml of 0.9% isotonic sodium chloride |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Perfusion index | The perfusion of the tissues | six months |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Heart rate | six months |
| Blood pressure | Non-invasive lood pressure | six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Seval Ekerer, Dr | Gaziosmanpasa University | Principal Investigator |
| Mustafa Suren, Dr | Gaziosmanpasa University | Principal Investigator |
| Serkan Karaman, Dr | Gaziosmanpasa University | Principal Investigator |
| Tugba Karaman, Dr | Gaziosmanpasa University | Principal Investigator |
| Hakan Tapar, Dr | Gaziosmanpasa University | Principal Investigator |
| Aynur Sahin, Dr | Gaziosmanpasa University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gaziosmanpasa University | Tokat Province | 60200 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D006895 | Hydroxyethyl Starch Derivatives |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| Hydroxyethylstarch |
| Drug |
500 ml of 6% Hydroxyethylstarch |
|
| Ringer-Lactate Infusion Solution Bag | Drug | 500 ml of Ringer-Lactate Infusion Solution Bag |
|
| Oxygen saturation | Blood oxygen saturation using pulse oximeter | six months |
| Pulse variability index | The intravenous fluid requirement of the tissues | six months |
| D017670 |
| Sodium Compounds |
| D013213 | Starch |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005936 | Glucans |
| D011134 | Polysaccharides |