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Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RYGB patients with preoperative type diabetes | Recruited from a previously investigated cohort (NCT 01202526) |
| |
| RYGB patients with preoperative normal glucose tolerance | Recruited from a previously investigated cohort (NCT 01202526) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Roux-en-Y gastric bypass | Procedure | Roux-en-Y gastric bypass surgery for morbid obesity |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in bone mineral density of non-weight bearing bone | DXA scans of forearm | 1 year, 4 years |
| Changes in bone mineral density of weightbearing bone | DXA scans of hip and lumbal columna | 1 year, 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma markers of bone turnover | At fasting | 1 week, 3 months, 1 year, 4 years |
| Plasma markers of bone turnover | during OGTT | 3 months, 1 year, 4 years |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be recruited from a previously investigated cohort of 20 subjects undergoing Roux-en-Y gastric bypass surgery (NCT 01202526). The previous study aimed at investigating acute and long term changes in insulin sensitivity and secretion, whereas the present follow-up study investigates changes in bone metabolism as the primary outcome.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kirstine N Bojsen-Møller, MD, PhD | Contact | 4538626371 | kirstine.bojsen-moeller@regionh.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Copenhagen University hospital Hvidovre | Recruiting | Copenhagen | 2820 | Denmark |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015390 | Gastric Bypass |
| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
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Plasma and serum
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D005763 |
| Gastroenterostomy |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D013505 | Digestive System Surgical Procedures |