Comparison of RF and crYoballoon ablatiOn Therapy of AF（CRYO-AF）

Cryoballoon Versus Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation: A Multi-center, Prospective, Randomized, Controlled Study

It's a multi-center, prospective, randomized, controlled clinical trial of cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation.

The hypothesis of this study is that pulmonary vein isolation with cryoballoon ablation is not inferior to radiofrequency ablation with 3D mapping with respect to clinical safety and efficacy.

Inclusion Criteria:

• ECG recording of atrial fibrillation
• first time of ablation
• refractory to at least one anti-arrhythmia drug
• sign informed consent for participation in the study

Exclusion Criteria:

• had ablation before
• serious heart failure
• left atrial diameter>55mm
• Myocardial infarction, heart surgery or coronary intervention in 3 months before the ablation
• Stroke in 6 months before the ablation
• Endocardial thrombosis