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Investigator leaving the institution
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status. This study will examine the association between impairment in smell and taste and nutritional and functional markers among patients with end stage renal disease, as well as risk factors for smell and taste impairment.
People with advanced chronic kidney disease (CKD) are at risk for malnutrition, which is associated with significantly increased mortality. Impairments in olfaction and taste are under-recognized and under-addressed symptoms that affect this population. Olfaction and taste influence appetite and nutritional status and represent a unique target for study and intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general population, but little is known about longitudinal change in olfaction and taste in this population. Additionally, there is a lack of understanding about why these sensory disturbances more commonly occur in people with CKD, although there is speculation that uremia may contribute.
This information gained from this study will address these gaps in knowledge by studying longitudinal changes in olfaction and taste and their associations with concurrent and future nutritional and functional status. Additionally this study will attempt to identify potentially modifiable risk factors associated with olfactory and taste impairment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| End stage renal disease | Observational study, no intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Worsening of olfaction from enrollment visit to 6 months | Other | Worsening of olfaction from enrollment visit to 6 months will be evaluated for association with the primary and secondary outcomes |
| Measure | Description | Time Frame |
|---|---|---|
| change in lean body mass | lean body mass will be determined by dual-energy X-ray absorptiometry scan | from 6 months to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| change in hand grip strength | measured by dynamometer | from 6 months to 1 year |
| change in the physical function score | measured by Standard-Form 36 version 2 |
| Measure | Description | Time Frame |
|---|---|---|
| change in serum albumin | change in serum albumin | from 6 months to 1 year |
| change in dietary intake | measured by a food frequency questionnaire |
Inclusion Criteria:
Exclusion Criteria:
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Adults (aged 18 or older) who have end-stage renal disease requiring chronic dialysis.
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| Name | Affiliation | Role |
|---|---|---|
| Katherine Lynch, MD, SM | Beth Israel Deaconess Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States |
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| Worsening of taste from enrollment visit to 6 months | Other | Worsening of taste from enrollment visit to 6 months will be evaluated for association with the primary and secondary outcomes |
|
| Serum Zinc | Other | Serum zinc will be evaluated for association with taste and/or smell impairment |
|
| Chronic rhinosinusitis | Other | Chronic rhinosinusitis will be evaluated for association with smell impairment |
|
| Dialysis adequacy | Other | Dialysis adequacy will be evaluated for association with taste and/or smell impairment |
|
| Decayed missing filled teeth index (DMFT) | Other | DMFT will be evaluated for association with taste impairment |
|
| from 6 months to 1 year |
| from 6 months to 1 year |
| change in anthropometric measures | triceps skinfold thickness, mid arm circumference, and weight | from 6 months to 1 year |
| change in serum cholesterol | change in serum cholesterol | from 6 months to 1 year |
| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| D000857 | Olfaction Disorders |
| D013651 | Taste Disorders |
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C076035 | c-MYC-associated zinc finger protein |
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