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This study investigates the impact of endometrial scratching on endometrial secretion, when correlated to pregnancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No intervention | No Intervention | Standard treatment | |
| Intervention | Experimental | Endometrial scratching before standard treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pipelle de Cornier | Other | RCT with endometrial scratching prior to hormone treatment in ART. Aspiration of uterine secretion at transfer day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cytokine profile of the uterine secretome after therapeutic endometrial scratching | The secretome is analyzed using a Multiplex analysis with 45 cytokines, chemokines and growth factors from ProcartaPlex Immunoassay Kit, Affymetrix, eBioscience. The samples are normalized for total protein content using a Nanodrop spectrophometer, and the protein composition is further determined by sodium dodecyl sulphate-polyacrylamide gel electropheresis (SDS-PAGE). | Within 12 months |
| Immunoassay Kit: | BDNF, EGF, Eotaxin, FGF-2, GMCSF, GRO-alpha, HGF, IFN alpha, IFN gamma, IL-1RA, IL-1alpha, IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL17-A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10, LIF, MCP-1, MIP-1 alpha, MIP-1 beta, NGF beta, RANTES, PDGF-BB, PÃ…IGF-1, SCF, SDF-1 alpha, TNF alpha, TNF beta, VEGF-A, VEGF-D | Within 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Clinic,Aalborg University Hospital | Aalborg | Denmark | ||||
| Fertility Clinic, Herlev Hospital |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Randomized clinical trial
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| Herlev |
| Denmark |
| Fertility Clinic Horsens Hospital | Horsens | Denmark |
| Fertility Clinic, Skive Hospital | Skive | Denmark |
| D000091662 | Genital Diseases |
| D007246 | Infertility |