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The purpose of this study is to determine the effect of a combined vaccination schedule of the 13-valent pneumococcal conjugate (PCV13) and 23valent plain polysaccharide vaccine (PPV23) on the establishment of immunological memory in HIV-infected adults on ART.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PCV13 | Experimental |
| |
| PPV23 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PCV13 | Biological |
| ||
| PPV23 |
| Measure | Description | Time Frame |
|---|---|---|
| immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by flow cytometry) | immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by flow cytometry) | One month post-PCV13, PPV23 |
| immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by flow cytometry) | immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by flow cytometry) | One month post-PCV13, PPV23 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vana Spoulou | Greece 'Aghia Sophia' Children's Hospital Athens, Attiki, Greece, 11527 | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29722823 | Derived | Farmaki PF, Chini MC, Mangafas NM, Tzanoudaki MT, Piperi CP, Lazanas MZ, Spoulou VS. Immunogenicity and Immunological Memory Induced by the 13-Valent Pneumococcal Conjugate Followed by the 23-Valent Polysaccharide Vaccine in HIV-Infected Adults. J Infect Dis. 2018 Jun 5;218(1):26-34. doi: 10.1093/infdis/jiy135. |
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|
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
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