Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients

Study of the Immunogenicity and Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Adults

The purpose of this study is to determine the effect of a combined vaccination schedule of the 13-valent pneumococcal conjugate (PCV13) and 23valent plain polysaccharide vaccine (PPV23) on the establishment of immunological memory in HIV-infected adults on ART.

Inclusion Criteria:

• CD4 T cell count >200cells/μl
• on ART

Exclusion Criteria:

• no previously recorded allergy to PCV, PPV23
• no intravenous immunoglobulin (IVIG) given within the previous 6 months
• no other vaccine given within the previous 6 months