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The study aims to know whether starting progesterone luteal support in intra cytoplasmic sperm injection (ICSI) cycles on the day of ovum pickup affects the degree of difficulty of embryo transfer compared with starting luteal support on day of embryo transfer
Double blind Randomized Controlled Trial (RCT) : the clinicians and the patents were blinded of the allocation group.
A total of 137 embryo transfers were randomly allocated into either arm I (67 ) starting luteal support as daily IM injections of 100 mg prontogest on day of egg retrieval , or arm II (66) starting the same P4 dose on day of embryo transfer
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Egg retrieval arm | Experimental | 67 ICSI cases are started daily 100 mg IM prontogest on the day of egg retrieval until the day of pregnancy test. |
|
| Embryo transfer arm | Active Comparator | 66 ICSI cases are started daily 100 mg IM prontogest on the day of embryo transfer until the day of pregnancy test. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progesterone 100 IM/day | Drug | Progesterone IM 100 mg /day was started on day of egg retrieval in egg retrieval arm and on day of embryo transfer in the embryo transfer arm |
|
| Measure | Description | Time Frame |
|---|---|---|
| difficult embryo transfer | presence of blood on embryo transfer catheter and or need for sounding or dilating the cervix to pass the embryo transfer catheter to the endometrial cavity | 3 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| cycle outcome | clinical cycle pregnancy rate calculated as number of clinical pregnancies (gestational sacs shown by ultrasound ) per 100 cases transferred multiplied by 100.Implantation rate calculated by the outcome of dividing the total number of gestational sacs in the arm by the total number of embryos transferred. | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
infertile females undergoing first ICSI cycle
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16373409 | Background | Mochtar MH, Van Wely M, Van der Veen F. Timing luteal phase support in GnRH agonist down-regulated IVF/embryo transfer cycles. Hum Reprod. 2006 Apr;21(4):905-8. doi: 10.1093/humrep/dei437. Epub 2005 Dec 22. | |
| Background | Senciboy D.N and Sharpe-Timms K.L: Progesterone affects the cervix prior to embryo transfer. , Fertility and Sterility ,2001: 76 , Issue 3 , S220 - S221 | ||
| Background | Ghanem ME, Ragab AE, Alboghdady LA, Helal AS, Bedairy MH, Bahlol IA, Abdelaziz A. Difficult embryo transfer (ET) components and cycle outcome. Which is more harmful?. Middle East Fertility Society Journal. 2016 Jun 30;21(2):114-119 | ||
| 32909190 |
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Double blind Randomized Controlled Trial : the clinicians and the patents were blinded of the allocation group.
A total of 137 embryo transfers (ETs) were randomly allocated into either group A (67 ) starting luteal support as daily intra muscular (IM) injections of 100 mg prontogest on day of egg retrieval, or group B (66) starting the same P4 dose on day of embryo transfer.Transfer technique was blind tactile using Labotect catheter and was considered difficult if the inner ET catheter was blood stained and /or sounding or dilating the cervix was needed. Cervical traction or blood staining of outer sheath did not indicate difficulty
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The randomization
| Derived |
| Ghanem ME, Bedairy MH, Shaaban A, Albahlol IA. Does the Time of Starting Progesterone Luteal Support Affect Embryo Transfer in Long Agonist Protocol Downregulated ICSI Cycles? A Randomized Controlled Trial. Reprod Sci. 2021 Mar;28(3):897-903. doi: 10.1007/s43032-020-00309-0. Epub 2020 Sep 9. |