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Multicentre cohort study on the use of endoscopic submucosal dissection for the treatment of early gastrointestinal neoplasia.
Data will be collected from participating centres on en bloc resection, curative resection, R0 resection and complications/adverse events over a 2 year follow up period.
Demographic details on the patients included in the study will be captured alongside details on the size and location of their early gastrointestinal dysplastic/neoplastic lesions.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endoscopic Submucosal Dissection | Procedure | Endoscopic submucosal dissection is an endoscopic resection technique that utilises an endoscopic knife to remove lesions within the gastrointestinal tract in an en bloc fashion. |
| Measure | Description | Time Frame |
|---|---|---|
| Curative resection rate | % of successful resections free of disease at follow up endoscopy by the end of the follow up period (2 years) | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| En bloc resection rate | % of en bloc resections obtained at the time of initial endoscopic submucosal dissection | At the time of procedure |
| Complication rates | % of complications noted within 28 days following endoscopic submucosal dissection |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing endoscopic submucosal dissection for early gastrointestinal neoplasia (e.g colorectal/gastric/oesophageal) in tertiary referral centres in the UK
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Prof Pradeep Bhandari, MBBS, MD | Contact | 02392286000 | 5852 | pradeep.bhandari@porthosp.nhs.uk |
| Sharmila Subramaniam, MBBS | Contact | 02392286000 | 5852 | Sharmila.Subramaniam@porthosp.nhs.uk |
| Name | Affiliation | Role |
|---|---|---|
| Prof Pradeep Bhandari, MBBS, MD | Portsmouth Hospitals NHS Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Portsmputh Hospitals NHS Trust | Recruiting | Portsmouth | PO6 3LY | United Kingdom |
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| ID | Term |
|---|---|
| D000069916 | Endoscopic Mucosal Resection |
| ID | Term |
|---|---|
| D016099 | Endoscopy, Gastrointestinal |
| D016145 | Endoscopy, Digestive System |
| D003938 | Diagnostic Techniques, Digestive System |
| D019937 | Diagnostic Techniques and Procedures |
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| 28 days post procedure |
| Mortality rates | % of patients alive at the end of the 2 year follow up | 2 years |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |