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| Name | Class |
|---|---|
| Queen's University | OTHER |
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The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver metastases, imaged with clinical CT scanners even in the setting of variable scan parameters and variable contrast timing. Participants will be consented to undergo an additional CT of their abdomen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort 1 | -15 second time gap between routine abdominal CT and add on CT, Noise Index of 12 |
| |
| Cohort 2 | -15 second time gap between routine abdominal CT and add on CT, Noise Index of 14 |
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| Cohort 3 | -15 second time gap between routine abdominal CT and add on CT, Noise Index of 16 |
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| Cohort 4 | -10 second time gap between routine abdominal CT and add on CT, Noise index 12 |
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| Cohort 5 | -10 second time gap between routine abdominal CT and add on CT, Noise index 14 |
| |
| Cohort 6 | -10 second time gap between routine abdominal CT and add on CT, Noise index 16 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT scan | Diagnostic Test | Patients with colorectal liver metastases scheduled for abdominopelvic CECT will be consented to undergo an additional CT of their abdomen (termed add-on CT) within 15 seconds, before or after, their clinical portal venous phase CT (PV CT), which is performed at a fixed delay of 80 seconds at our institution. |
| Measure | Description | Time Frame |
|---|---|---|
| assess the stability (reproducibility) of radiomic measurements obtained from repeat abdominal CT scans | There will be 18 cohorts, each cohort differing by the length of the time gap in acquisition and noise index. In addition each acquisition will be reconstructed in 21 different ways (combinations of 3 slice thicknesses and 7 ASiR levels). | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who undergo contrast enhanced CT scanning for colorectal liver metastases will be consented for one additional CT abdomen phase during the same imaging session.
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| Name | Affiliation | Role |
|---|---|---|
| Kinh Gian Richard Do, MD, PhD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | ||
| MD Anderson Cancer Center, Texas (Data collection only) |
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| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Jun 22, 2022 | Apr 14, 2025 | ICF_000.pdf |
| ID | Term |
|---|---|
| D014057 | Tomography, X-Ray Computed |
| ID | Term |
|---|---|
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Cohort 7 | - 5 second time gap between routine abdominal CT and add on CT, Noise index 12 |
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| Cohort 8 | - 5 second time gap between routine abdominal CT and add on CT, Noise index 14 |
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| Cohort 9 | - 5 second time gap between routine abdominal CT and add on CT, Noise index 16 |
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| Cohort 10 | + 5 second time gap between routine abdominal CT and add on CT, Noise index 12 |
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| Cohort 11 | + 5 second time gap between routine abdominal CT and add on CT, Noise index 14 |
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| Cohort 12 | + 5 second time gap between routine abdominal CT and add on CT, Noise index 16 |
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| Cohort 13 | + 10 second time gap between routine abdominal CT and add on CT, Noise index 12 |
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| Cohort 14 | + 10 second time gap between routine abdominal CT and add on CT, Noise index 14 |
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| Cohort 15 | + 10 second time gap between routine abdominal CT and add on CT, Noise index 16 |
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| Cohort 16 | + 15 second time gap between routine abdominal CT and add on CT, Noise 12 |
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| Cohort 17 | + 15 second time gap between routine abdominal CT and add on CT, Noise 14 |
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| Cohort 18 | + 15 second time gap between routine abdominal CT and add on CT, Noise 16 |
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| Houston |
| Texas |
| 77030 |
| United States |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D014054 | Tomography |