due to organisational changes

Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples. In many hospitals that is still not an option. The investigators aim to show, that computer based calculation can avoid over- or under-dosing.

Adequate dosing of antiinfective therapy in critically ill patients is most important to improve outcome. Patients with impaired or lost renal function or continuous renal replacement therapy are hard to calculate using drug information sheets or "lists" with recommendations. It is nearly impossible to avoid drug levels that are much to low or much to high without measuring the concentration in blood samples. Since that possibility is still not available in every clinic we aim to show, how a computer based calculation can help to find the adequate dosing.

Inclusion Criteria:

• patients requiring antiinfective therapy
• patients with impaired renal function or requiring continuous renal replacement therapy

Exclusion Criteria:

• plasmapheresis or liver replacement therapy
• renal replacement therapy with integrated CytoSorb®-Membrane
• extracorporal live support

critically ill patients with impaired renal function and antiinfective therapy