Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients

The aim of this study is to determine if amiloride, a diuretic drug, is capable of increasing renal salt excretion, lowering blood pressure and inhibiting uPA in kidney transplant recipients with proteinuria compared to normoalbuminuric transplant patients.

Inclusion Criteria:

• One Group of kidney transplant recipients with ACR< 30mg/g
• One Group of kidney transplant recipients with ACR >300mg/g

Exclusion Criteria:

• Treatment with amiloride, spironolactone, aldosterone- or analogs or tranexamsyre
• Pregnancy
• Clinically relevant organic or systemic disease including malignancy
• eGFR or creatinin-clearance < 30ml/min
• hyperkalemia (s-potassium > 5,0mmol/l)