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| Name | Class |
|---|---|
| Odense University Hospital | OTHER |
| Region of Southern Denmark | OTHER |
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The aim of this study is to determine if amiloride, a diuretic drug, is capable of increasing renal salt excretion, lowering blood pressure and inhibiting uPA in kidney transplant recipients with proteinuria compared to normoalbuminuric transplant patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TX control | Experimental | Kidney transplant recipients with urinary albumin/creatinin-ratio < 30mg/g |
|
| TX Proteinuria | Experimental | Kidney transplant recipients with urinary albumin/creatinin-ratio > 300mg/g |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standardized sodium diet | Dietary Supplement | Dietary Supplement: Standardized salt diet 150 mmol NaCl per day given as three meals daily for 5 consecutive days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour urinary sodium excretion induced by amiloride | Change from baseline urinary sodium (after 4 days of standadized sodium diet) excretion at 24 hours after amiloride administration |
| Measure | Description | Time Frame |
|---|---|---|
| Office or 24h blood pressure measurements | Change from baseline office blood pressure at day 4 of salt diet and at 24 hours after amiloride administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gitte Rye Hinrichs, MD, PHD | Cardiovascular and Renal research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Odense University Hospital | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38254266 | Derived | Isaksson GL, Hinrichs GR, Andersen H, Bach ML, Weyer K, Zachar R, Henriksen JE, Madsen K, Lund IK, Mollet G, Bistrup C, Birn H, Jensen BL, Palarasah Y. Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria. J Am Soc Nephrol. 2024 Apr 1;35(4):410-425. doi: 10.1681/ASN.0000000000000312. Epub 2024 Jan 23. |
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| ID | Term |
|---|---|
| D004032 | Diet |
| D000584 | Amiloride |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D011719 | Pyrazines |
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Experimental: Kidney transplant recipients with ACR > 300mg/g receiving standardized sodium diet (150 mmol NaCl/day) for 5 days and amiloride tablet 10 mg two times daily (morning and afternoon) on the last day.
Interventions:◦Dietary Supplement: Standardized salt diet
◦Drug: Amiloride
•Experimental: Kidney transplant recipient with ACR< 30mg/g (Control) receiving a standardized salt diet (150 mmol NaCl/day) for 5 days, then amiloride tablet 10 mg two times daily (morning and afternoon) for 1 day.
Interventions:◦Dietary Supplement: Standardized salt diet
◦Drug: Amiloride
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open label
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|
| Tbl amiloride | Drug | Drug: Amiloride Amiloride tablet 10 mg two times daily (morning and afternoon) for one day |
|
|
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |