Pharmacokinetics of Epinephrine During Cardiac Arrest

Pharmacokinetic Study of Epinephrine During Cardiac Arrest Determining T1/2 and Time to Peak Concentration

To determine the pharmacokinetics of epinephrine during cardiac arrest.

The aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. Venous samples will be withdrawn every minute the first five minutes following a single dose.

The aim of the study is to determine T1/2 in a clinical setting and to determine time to peak concentration.

Inclusion Criteria:

• Age 18-85 yrs
• Witnessed non-traumatic cardiac arrest.
• Probable cardiac origin
• Treated by Bergen Emergency Medical Services

Exclusion Criteria:

• Terminal illness
• Residents of nursery homes
• Obvious dead
• Hypothermic patients
• Epinephrine administered before arrival of study physician