Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 3R210Z893430 | Other Grant/Funding Number | Jilin Provincial Department of Science and Technology |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study evaluates the effect of transversus abdominis plane(TAP) block combined with general anesthesia on perioperative stress response in patients undergoing radical gastrectomy. One third of participants will receive TAP block combined with general anesthesia, another one third of participants will receive epidural anesthesia combined with general anesthesia, while the rest will receive only general anesthesia.
Clinically, combining epidural with general anaesthesia may confer many advantages to patients undergoing major thoracic, abdominal or orthopaedic surgery. Epidural anaesthesia can attenuate sympathetic hyperactivity and the stress response, maintain bowel peristalsis, spare the use of opioids, and facilitate postoperative feeding and physiotherapy. However, establishing epidural anesthesia is not without risks and contraindications, including refusal by the patient, technical failure, unintentional dural puncture, waist and back pain and local anaesthetic toxicity. When neurologic complications do occur, the resulting morbidity and mortality is considerable. Transversus abdominis plane (TAP) block, is another new regional anesthesia technique, has been introduced as an abdominal wall block capable of providing effective analgesia, reducing opioid consumption, and lessening opioid-related side effects. In addition,TAP block, somewhat as a pre-emptive analgesia approach, is a way of pain intervention before noxious stimulation which has been reported to be potent to attenuate the stress response. Although the analgesia efficiency of TAP block has been widely studied, its effectiveness to suppress stress response has little comparison with classic epidural block and general anesthesia. Unlike epidural anaesthesia, TAP block is easy to administer and lower incidence for side-effects.The investigators hypothesize that the TAP block reduces the stress response of surgery to the similar extent to epidural anaesthesia when combined with a standard general anaesthesia for abdominal surgery.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transversus abdominis plane block | Experimental | The TAP group receives ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia. |
|
| Epidural anesthesia | Active Comparator | The Epidural group receives epidural block (T8-9) 2 mL of 1.6% lidocaine as a test dose and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. |
|
| Control | Placebo Comparator | The Control group receives standard IV-inhaled general anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transversus abdominis plane block | Other | Participants in this group receive ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia, 30 minutes later the surgery will be started. |
| Measure | Description | Time Frame |
|---|---|---|
| Physiological Parameters: Plasma Concentration of Norepinephrine (NE) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The NE levels are measured by ELISA kits. | up to 48h after surgery |
| Physiological Parameters: Plasma Concentration of Epinephrine (E) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The E levels are measured by ELISA kits. | up to 48h after surgery |
| Physiological Parameters: Plasma Concentration of Cortisol (Cor) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The Cor levels are measured by ELISA kits. | up to 48h after surgery |
| Physiological Parameters: Plasma Concentration of Glucose (Glu) | When venous blood are collected, glucose levels are measured immediately by Glucometer. | up to 48h after surgery |
| Hemodynamic Parameters: Heart Rate. | Continuous monitoring of heart rate to 48 hours after surgery. | up to 48h after surgery |
| Hemodynamic Parameters: Mean Arterial Pressure(MAP) | Continuous monitoring of mean arterial pressure(MAP) to 48 hours after surgery. mean arterial pressure(MAP)＝ (systolic blood pressure＋2×diastolic blood pressure)/3 |
| Measure | Description | Time Frame |
|---|---|---|
| Anesthetics Consumption: Sufentanil Consumption | Intraoperative superaddition of sufentanil was measured. | during operation |
| Questionnaire: Pain Scores at Rest | Pain scores of the participants will be measured by the Visual Analogue Scale. Measurement of VAS: Draw a 10cm horizontal line on the paper. The VAS were anchored at 0cm(no pain) and 10cm(worst possible pain), the middle part shows varying degrees of pain, the greater of the number, the worse of the pain. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Guoqing Zhao, doctor | Jilin University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China-Japan Union Hospital of Jilin University | Changchun | Jilin | 130000 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
According to the analysis by PASS 11.0, at lease 25 participants each arm were needed.Taking into account the withdrawal of patients in the middle of the study, each group were more than a few included
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Transversus Abdominis Plane Block | The TAP group receives ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia. Transversus abdominis plane block: Participants in this group receive ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia, 30 minutes later the surgery will be started. |
| FG001 | Epidural Anesthesia | The Epidural group receives epidural block (T8-9) 2 mL of 1.6% lidocaine as a test dose and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. Epidural anesthesia: Participants in the Epidural group receive a epidural block (T8-9) with 2 mL of 1.6% lidocaine as a test dose before induction. After a successful placement of epidural catheter, the block then is established with 5 mL of 0.375% ropivacaine and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. |
| FG002 | Control | The Control group receives standard IV-inhaled general anesthesia. control: The Control group receives standard IV-inhaled general anesthesia. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Transversus Abdominis Plane Block | The TAP group receives ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia. Transversus abdominis plane block: Participants in this group receive ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia, 30 minutes later the surgery will be started. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Physiological Parameters: Plasma Concentration of Norepinephrine (NE) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The NE levels are measured by ELISA kits. | Posted | Mean | Standard Deviation | pg/ml | up to 48h after surgery |
|
1 month
Not provided
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Transversus Abdominis Plane Block | The TAP group receives ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia. Transversus abdominis plane block: Participants in this group receive ultrasound-guided TAP block under bilateral costal margin with multiple injections of 40ml 0.375% ropivacaine after the induction of general anesthesia, 30 minutes later the surgery will be started. |
Not provided
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Headache | Nervous system disorders | Non-systematic Assessment |
Firstly, early termination leading to small numbers of subjects analyzed. Secondly, sufentanil for analgesia, known to have effects on neuroimmunoendocrine network, which may have influenced our finding.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Guoqing Zhao | China-Japan Unit Hospital of Jilin University | 0435-84995117 | zhaogq65@126.com |
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jan 30, 2017 | Sep 25, 2017 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Jan 30, 2017 | Sep 25, 2017 | SAP_001.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jan 30, 2017 | Sep 25, 2017 | ICF_002.pdf |
Not provided
| ID | Term |
|---|---|
| D015775 | Fractures, Stress |
| ID | Term |
|---|---|
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
Not provided
Not provided
| ID | Term |
|---|---|
| D000767 | Anesthesia, Epidural |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Epidural anesthesia | Other | Participants in the Epidural group receive a epidural block (T8-9) with 2 mL of 1.6% lidocaine as a test dose before induction. After a successful placement of epidural catheter, the block then is established with 5 mL of 0.375% ropivacaine and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. |
|
| control | Other | The Control group receives standard IV-inhaled general anesthesia. |
|
| up to 48h after surgery |
| 1hr, 6hr, 12hr, 24hr, and 48hr after surgery |
| Questionnaire: Pain Scores on Movement | Pain scores of the participants will be measured by the Visual Analogue Scale. Measurement of VAS: Draw a 10cm horizontal line on the paper. The VAS were anchored at 0cm(no pain) and 10cm(worst possible pain), the middle part shows varying degrees of pain, the greater of the number, the worse of the pain. | 1hr, 6hr, 12hr, 24hr, and 48hr after surgery |
| Anesthesia Recovery: the Time of First Flatus | The time of first flatus was measured after surgery. | Through study completion, an average of 2 weeks |
| Anesthesia Recovery: Number of Participants With Prolonged Hospitalization | The percentage of long hospitalization were measured. More than 7 days after surgery is defined as prolonged hospitalization. | Through study completion, an average of 2 weeks |
| Side Effects: Number of Participants With Sedation | The state of sedation was evaluated after surgery during first postoperative 48 hours. | up to 48h after surgery |
| Side Effects: Number of Participants With Nausea | The state of nausea was evaluated after surgery during first postoperative 48 hours. | up to 48h after surgery |
| Side Effects: Number of Participants With Vomiting | The state of vomiting was evaluated after surgery during first postoperative 48 hours. | up to 48h after surgery |
| BG001 | Epidural Anesthesia | The Epidural group receives epidural block (T8-9) 2 mL of 1.6% lidocaine as a test dose and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. Epidural anesthesia: Participants in the Epidural group receive a epidural block (T8-9) with 2 mL of 1.6% lidocaine as a test dose before induction. After a successful placement of epidural catheter, the block then is established with 5 mL of 0.375% ropivacaine and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. |
| BG002 | Control | The Control group receives standard IV-inhaled general anesthesia. control: The Control group receives standard IV-inhaled general anesthesia. |
| BG003 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Race/Ethnicity, Customized | Number | participants |
|
| ASA physical status | ASA I: No organic, physiologic, biochemical or psychiatric disturbance; ASA II: A patient with mild systemic disease that results in no functional limitation; ASA III: A patient with severe systemic disease that results in functional impairment; ASA IV: Severe systemic disease that is a constant threat to life; ASA V: Moribund condition in a patient who is not expected to survive with or without the operation; ASA VI: Declared brain death patient whose organs are being harvested for transplantation; E: Emergency operation is required. | Count of Participants | Participants |
|
| OG001 | Epidural Anesthesia | The Epidural group receives epidural block (T8-9) 2 mL of 1.6% lidocaine as a test dose and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. Epidural anesthesia: Participants in the Epidural group receive a epidural block (T8-9) with 2 mL of 1.6% lidocaine as a test dose before induction. After a successful placement of epidural catheter, the block then is established with 5 mL of 0.375% ropivacaine and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. |
| OG002 | Control | The Control group receives standard IV-inhaled general anesthesia. control: The Control group receives standard IV-inhaled general anesthesia. |
|
|
|
| Primary | Physiological Parameters: Plasma Concentration of Epinephrine (E) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The E levels are measured by ELISA kits. | Posted | Mean | Standard Deviation | pg/ml | up to 48h after surgery |
|
|
|
|
| Primary | Physiological Parameters: Plasma Concentration of Cortisol (Cor) | Venous blood samples will be collected at certain time points. The blood samples are collected in a pre-chilled tubes in ice and are centrifuged within 90min, and then separated plasma are stored at -80°C until analysis. The Cor levels are measured by ELISA kits. | Posted | Mean | Standard Deviation | mmol/L | up to 48h after surgery |
|
|
|
|
| Primary | Physiological Parameters: Plasma Concentration of Glucose (Glu) | When venous blood are collected, glucose levels are measured immediately by Glucometer. | Posted | Mean | Standard Deviation | mmol/L | up to 48h after surgery |
|
|
|
|
| Primary | Hemodynamic Parameters: Heart Rate. | Continuous monitoring of heart rate to 48 hours after surgery. | Posted | Mean | Standard Deviation | bpm | up to 48h after surgery |
|
|
|
|
| Primary | Hemodynamic Parameters: Mean Arterial Pressure(MAP) | Continuous monitoring of mean arterial pressure(MAP) to 48 hours after surgery. mean arterial pressure(MAP)＝ (systolic blood pressure＋2×diastolic blood pressure)/3 | Posted | Mean | Standard Deviation | mmHg | up to 48h after surgery |
|
|
|
|
| Secondary | Anesthetics Consumption: Sufentanil Consumption | Intraoperative superaddition of sufentanil was measured. | Posted | Mean | Standard Deviation | ug | during operation |
|
|
|
|
| Secondary | Questionnaire: Pain Scores at Rest | Pain scores of the participants will be measured by the Visual Analogue Scale. Measurement of VAS: Draw a 10cm horizontal line on the paper. The VAS were anchored at 0cm(no pain) and 10cm(worst possible pain), the middle part shows varying degrees of pain, the greater of the number, the worse of the pain. | Posted | Mean | Standard Deviation | units on a scale | 1hr, 6hr, 12hr, 24hr, and 48hr after surgery |
|
|
|
|
| Secondary | Questionnaire: Pain Scores on Movement | Pain scores of the participants will be measured by the Visual Analogue Scale. Measurement of VAS: Draw a 10cm horizontal line on the paper. The VAS were anchored at 0cm(no pain) and 10cm(worst possible pain), the middle part shows varying degrees of pain, the greater of the number, the worse of the pain. | Posted | Mean | Standard Deviation | units on a scale | 1hr, 6hr, 12hr, 24hr, and 48hr after surgery |
|
|
|
|
| Secondary | Anesthesia Recovery: the Time of First Flatus | The time of first flatus was measured after surgery. | Posted | Mean | Standard Deviation | hour | Through study completion, an average of 2 weeks |
|
|
|
|
| Secondary | Anesthesia Recovery: Number of Participants With Prolonged Hospitalization | The percentage of long hospitalization were measured. More than 7 days after surgery is defined as prolonged hospitalization. | Posted | Number | participants | Through study completion, an average of 2 weeks |
|
|
|
|
| Secondary | Side Effects: Number of Participants With Sedation | The state of sedation was evaluated after surgery during first postoperative 48 hours. | Posted | Number | participants | up to 48h after surgery |
|
|
|
|
| Secondary | Side Effects: Number of Participants With Nausea | The state of nausea was evaluated after surgery during first postoperative 48 hours. | Posted | Number | participants | up to 48h after surgery |
|
|
|
|
| Secondary | Side Effects: Number of Participants With Vomiting | The state of vomiting was evaluated after surgery during first postoperative 48 hours. | Posted | Number | participants | up to 48h after surgery |
|
|
|
|
| 0 |
| 30 |
| 0 |
| 30 |
| 0 |
| 30 |
| EG001 | Epidural Anesthesia | The Epidural group receives epidural block (T8-9) 2 mL of 1.6% lidocaine as a test dose and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. Epidural anesthesia: Participants in the Epidural group receive a epidural block (T8-9) with 2 mL of 1.6% lidocaine as a test dose before induction. After a successful placement of epidural catheter, the block then is established with 5 mL of 0.375% ropivacaine and continous infusion of 0.375% ropivacaine(5 mL/h) during the surgery. | 0 | 28 | 0 | 28 | 2 | 28 |
| EG002 | Control | The Control group receives standard IV-inhaled general anesthesia. control: The Control group receives standard IV-inhaled general anesthesia. | 0 | 31 | 0 | 31 | 0 | 31 |
Not provided
Not provided
Not provided
|
| 6 hr after surgery |
|
| 24 hr after surgery |
|
| 48 hr after surgery |
|
| t-test, 2 sided |
| 0.592 |
| Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "Baseline" row. | t-test, 2 sided | 0.796 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.576 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.427 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.201 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.872 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.165 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.305 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of epinephrine (E) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
|
| 6 hr after surgery |
|
| 24 hr after surgery |
|
| 48 hr after surgery |
|
| t-test, 2 sided |
| 0.824 |
| Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Baseline" row. | t-test, 2 sided | 0.547 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.303 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.026 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.002 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.057 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.069 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.561 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of cortisol (Cor) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
|
| 6 hr after surgery |
|
| 24 hr after surgery |
|
| 48 hr after surgery |
|
| t-test, 2 sided |
| 0.091 |
| Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Baseline" row. | t-test, 2 sided | 0.493 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.067 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "0 hour after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.079 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.314 | The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.087 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.023 | Other |
| The plasma level of glucose (Glu) were detected from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
|
| Induction |
|
| Intubation |
|
| Incision |
|
| Extubation |
|
| 6 hr after surgery |
|
| 24 hr after surgery |
|
| 48 hr after surgery |
|
| t-test, 2 sided |
| 0.530 |
| Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Baseline" row. | t-test, 2 sided | 0.819 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.108 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.667 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.046 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.006 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.406 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.042 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.655 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.262 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.143 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.494 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.001 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.001 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.555 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.411 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.167 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.445 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.489 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.159 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.720 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.026 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.011 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.763 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.187 | Other |
| The Heart rate was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.112 | Other |
|
| Induction |
|
| Intubation |
|
| Incision |
|
| Extubation |
|
| 6 hr after surgery |
|
| 24 hr after surgery |
|
| 48 hr after surgery |
|
| t-test, 2 sided |
| 0.645 |
| Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Baseline" row. | t-test, 2 sided | 0.314 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.003 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.367 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Before induction" row. | t-test, 2 sided | 0.031 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.009 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.873 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Induction" row. | t-test, 2 sided | 0.026 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.411 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.787 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Intubation" row. | t-test, 2 sided | 0.306 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.921 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.001 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Incision" row. | t-test, 2 sided | 0.001 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.555 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.058 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "Extubation" row. | t-test, 2 sided | 0.166 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.288 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.299 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.051 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.186 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.555 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.065 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.168 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.739 | Other |
| The mean arterial pressure(MAP) was measured from baseline to 48hours after surgery. The row "Baseline" is the preoperative level as the blank control.This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.079 | Other |
| Other |
| t-test, 2 sided | 0.001 | Other |
|
| 12 hr |
|
| 24 hr |
|
| 48 hr |
|
The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "1 hour after surgery" row.
| t-test, 2 sided |
| 0.009 |
p<0.05 indicates that the data difference is statistically significant. |
| Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "1 hour after surgery" row. | t-test, 2 sided | 0.001 | p<0.05 indicates that the data difference is statistically significant. | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.198 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.047 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.002 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.102 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.005 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.023 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.425 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.124 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.052 | Other |
|
| 12 hr |
|
| 24 hr |
|
| 48 hr |
|
The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "1 hour after surgery" row.
| t-test, 2 sided |
| 0.001 |
p<0.05 indicates that the data difference is statistically significant. |
| Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.228 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "6 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.057 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "12 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.004 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.005 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "24 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.002 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.002 | Other |
| The pain score were measured from 1 hour to 48hours after surgery. This Statistical Analysis applied to "48 hours after surgery" row. | t-test, 2 sided | 0.001 | Other |
| Other |
| t-test, 2 sided | 0.13 | Other |
| Other |
| t-test, 2 sided | 0.031 | Other |
| Other |
| t-test, 2 sided | 0.007 | Other |
| Other |
| t-test, 2 sided | 0.785 | Other |
| Other |
| t-test, 2 sided | 0.518 | Other |