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| Name | Class |
|---|---|
| Givaudan France Naturals | INDUSTRY |
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Purpose: To evaluate the acute and chronic effects of a botanical supplement on strength, muscle function, and lean body mass
Participants: The acute phase will include 30 participants, and the chronic phase will include 84 participants. All participants must be healthy recreationally active males between the ages of 18 and 35 years.
Procedures (methods):
Acute phase: Participants will complete three testing visits as part of as part of a cross-over design, during which strength and muscle function will be assessed prior to and following consumption of a supplement. The experimental supplement is a blend of the botanical extracts; treatment arms will include a full dose (FULL; 350 mg capsule), half dose (HALF; 175 mg plus maltodextrin), or placebo (PLA; maltodextrin).
Chronic phase: Body composition, muscle cross-sectional area, a complete blood count and metabolic panel, subjective surveys, and strength will be measured prior to and following an 8-week supervised resistance training program, in conjunction with daily supplementation of FULL, HALF, or PLA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CS16-003 Full dose | Experimental | 350 mg capsule QD Rhodiola rosea L. & Rhaptonticum carthamoides extracts |
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| CS16-003 Half dose | Experimental | 175 mg capsule QD 50% Rhodiola rosea L. & Rhaptonticum carthamoides extracts + 50% Maltodextrin |
|
| Placebo | Placebo Comparator | Maltodextrin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CS16-003 Full dose | Dietary Supplement | 350 mg 'Rhodiola rosea L. & Rhaptonticum carthamoides extracts |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximal Isokinetic Leg Extension strength measured by dynamometry | Acute/Immediate | |
| Maximal Upper and Lower Body Strength measured by 1 repetition maximum | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Bench Press Repetitions to Fatigue | 8 weeks | |
| Leg Press Repetitions to Fatigue | 8 weeks | |
| Body Composition-Lean Mass |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Ryan, PhD | University of North Carolina, Chapel Hill | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of North Carolina, Department of Exercise and Sport Science | Chapel Hill | North Carolina | 27599 | United States |
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| CS16-003 Half dose | Dietary Supplement | 175 mg 'Rhodiola rosea L. & Rhaptonticum carthamoides extracts + maltodextrin 175 mg |
|
| Placebo | Dietary Supplement | Maltodextrin: 350 mg |
|
| 8 weeks |
| Body Composition-Fat Mass | 8 weeks |
| Muscle cross sectional area | 8 weeks |
| Change in Quality of Life Score from baseline to 8 weeks | Quality of life from a visual analog scale (VAS) 0-100, with 0 = worst quality of life and 100=best quality of life. | baseline, 8 weeks |
| Change in Felt Arousal score from baseline to 8 weeks | Felt arousal scale. Scores range 1-6 with 1 being low arousal and 6 being high. One score selected. | baseline, 8 weeks |
| Change in Mood score from baseline to 8 weeks | Mood determined from a VAS. 0-100, with 0 = not depressed at all and 100 = most depressed. | baseline; 8 weeks |