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| ID | Type | Description | Link |
|---|---|---|---|
| U01AG019069 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| University of Iowa | OTHER |
| University of Alabama at Birmingham | OTHER |
| Boston University | OTHER |
| National Institute on Aging (NIA) |
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The purpose of this study is to investigate opportunities for prevention and treatment of knee osteoarthritis (OA) by evaluating potentially modifiable risk factors for disease and poor pain and physical function outcomes especially among those with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.
MOST study participants in the "Existing Cohort" (3,026 subjects) were enrolled in the original study in 2003-2005. Surviving Existing Cohort participants without end-stage knee osteoarthritis will be asked to participate in the 144-, 152-, 160- and 168-month follow-up contacts. In addition, in 2016-2018 the cohort will be enriched by the recruitment of an additional 1,500 "New Cohort" participants with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early or mild knee symptoms | Existing Cohort study participants (3,026) were enrolled in 2003-2005, Surviving participants without endstage knee osteoarthritis will be asked to participate in the 144-, 152-, 160- and 168-month follow-up contacts [2,660 were enrolled]. New Cohort study participants (1,500) will be recruited and enrolled in 2016-2018 [1,525 were enrolled]. |
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| Measure | Description | Time Frame |
|---|---|---|
| Worsening knee pain | Worsening knee pain defined as reaching minimally clinically important difference (MCID) for worsening on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain questionnaire | Change from baseline (144-month) at ≥2 follow-up contacts (152-, 160-, 168-month follow-up contacts) |
| Incident cartilage loss on MRI | Incidence of cartilage loss on MRI extending to the bone | Change from baseline (144-month) at 168-month follow-up contact |
| Function loss | Defined as minimally clinically important difference (MCID) for worsening on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function questionnaire | Change from baseline (144-month) at ≥2 follow-up contacts (152-, 160-, 168-month follow-up contacts) |
| Measure | Description | Time Frame |
|---|---|---|
| Onset of constant knee pain | Self- report | Change from baseline (144-month) at ≥2 follow-up contacts (152-, 160-, 168-month follow-up contacts) |
| Worsening on MRI | Worsening cartilage scores, bone marrow lesion, or meniscal damage |
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Inclusion Criteria for "New Cohort" Participants:
Exclusion Criteria for "New Cohort" Participants:
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The purpose of this study is to investigate opportunities for prevention and treatment of knee osteoarthritis by evaluating potentially modifiable risk factors for disease and poor pain and physical function outcomes especially among those with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.
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| Name | Affiliation | Role |
|---|---|---|
| Michael Nevitt, PhD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States | ||
| University of Iowa |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34620738 | Derived | Rabe KG, Stockman TJ, Kern AM, Wirth W, Eckstein F, Sharma L, Lynch JA, Nevitt MC, Anderson DD, Segal NA. Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study. Am J Phys Med Rehabil. 2022 Aug 1;101(8):726-732. doi: 10.1097/PHM.0000000000001899. Epub 2021 Oct 8. |
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Anonymized clinical data will be shared via The NIA Biobank (https://agingresearchbiobank.nia.nih.gov/). MOST Existing Cohort data from previous grant cycles will be available in mid 2021. For more information visit MOST Online (https://most.ucsf.edu).
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See NIA Biobank website
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| NIH |
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Existing Cohort biospecimens were collected at enrollment, 30-month and 60-month follow-up. New Cohort biospecimens will be collected at 144-month which will be their enrollment visit).
| Change from baseline (144-month) at 168-month follow-up contact |
| Worsening on X-ray | Increased Kellgren-Lawrence (KL) grade score, new KL grade 2 score, or semi-quantitative joint space loss in any compartment | Change from baseline (144-month) at 168-month follow-up contact |
| New onset knee buckling | Self-report | Change from baseline (144-month) at ≥1 follow-up contact (152-, 160-, 168-month follow-up contacts) |
| New repeated falls | Self-report | Change from baseline (144-month) at ≥1 follow-up contact (152-, 160-, 168-month follow-up contacts) |
| Iowa City |
| Iowa |
| 52240 |
| United States |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | United States |
| D012216 |
| Rheumatic Diseases |