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Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real Left DLPFC tDCS | Active Comparator | Real tDCS on the left dorsolateral prefrontal cortex |
|
| Sham tDCS | Sham Comparator | 30sec ramp-up and 30sec ramp-down |
|
| Real Right DLPFC tDCS | Active Comparator | Real tDCS on the right dorsolateral prefrontal cortex |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation | Device | 15 minute anodal stimulation 1.5mA |
|
| Measure | Description | Time Frame |
|---|---|---|
| functional connectivity | The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI. | immediate (less than 30 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Stroop task performance | the executive function that is thought to involve the caudate nucleus will be examined | immediate (less than 60 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Manitoba | Winnipeg | Manitoba | R3E 0J9 | Canada |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 27, 2026 | May 19, 2026 | 12 |
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |