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Background:
Primary hyperparathyroidism (PHPT) is often overlooked and underdiagnosed. At present the diagnosis of PHPT remains challenging and is based on serum calcium (Ca) and PTH.
As serum Ca and phosphorous (P) are inversely related in PHPT, the Ca/P ratio might be considered a good candidate tool in the diagnosis of PHPT.
AIM: The aim of this study is to investigate the diagnostic value of the Ca/P ratio in the diagnosis of PHPT.
Study design: Retrospective, observational, cross-sectional, case-control clinical trial will be carried out.
Biochemical measurements will include PTH, Vitamin D, serum Ca, P, albumin, and creatinine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Patients aged between 18-90 years old with primary hyperparathyroidism who had been diagnosed in the Unit of Endocrinology of the University of Modena and Reggio Emilia. The exclusion criteria will be:
|
| |
| Control group | Patients that underwent biochemical examination by primary care physician or by endocrinologist in order to assess their parathyroid function and calcium metabolism state with results into the normal ranges. The exclusion criteria will be:
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention are provided | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Calcium | Assay performed at the moment of diagnosis | Enrollment time |
| Measure | Description | Time Frame |
|---|---|---|
| Phosphorus | Assay performed at the moment of diagnosis | Enrollment time |
| Parathormone | Assay performed at the moment of diagnosis | Enrollment time |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with diagnosis of primary hyperparathyroidism
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda USL of Modena | Modena | Modena | 41126 | Italy |
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| ID | Term |
|---|---|
| D006961 | Hyperparathyroidism |
| ID | Term |
|---|---|
| D010279 | Parathyroid Diseases |
| D004700 | Endocrine System Diseases |
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| Creatinine | Assay performed at the moment of diagnosis | Enrollment time |
| Albumine | Assay performed at the moment of diagnosis | Enrollment time |
| Vitamin D | Assay performed at the moment of diagnosis | Enrollment time |