The primary objective of this study is to evaluate the long-term safety and tolerability of filgotinib in participants who have completed one of the parent studies of filgotinib in rheumatoid arthritis (RA).

Key Inclusion Criteria:

• Males or females who may benefit from filgotinib as judged by the investigator AND who completed a Gilead sponsored filgotinib parent study for RA as outlined below:

  • Have completed GS-US-417-0301, GS-US-417-0302 or GS-US-417-0303 on study drug

    • OR

  • Have completed GS-US-417-0302 on standard of care therapy due to RA non-responder status

• Females of childbearing potential must have a negative pregnancy test prior to first dose of study drug in the long term extension (LTE)

• Females of childbearing potential who engage in heterosexual intercourse must agree to protocol-approved methods of contraception

Key Exclusion Criteria:

• Diagnosis of an autoimmune or inflammatory joint disease other than RA, which would put the participant at risk by participating in the study or would interfere with study assessments/data interpretation, per judgment of the investigator
• Known hypersensitivity to the study drug or its excipients
• Any medical condition which would put the participant at risk by participating in the study or would interfere with study assessments/data interpretation, per judgment of the investigator

NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.

This study was originally designed and initiated as a double-blind study but the study design will change to open-label following implementation of the protocol amendment # 4.